Vasculitis and related conditions

Spatial transcriptomics reveals injury responsive compartments and coordinated immune fibrotic signaling in ANCA associated renal vasculitis

This study uses spatial transcriptomics to identify disease-responsive compartments and immune-fibrotic signaling in AAV kidney biopsies, linking them to histopathology and fibrotic injury.

Treatment of anti-myeloperoxidase glomerulonephritis using recombinant deoxyribonuclease I is enhanced by adeno-associated virus gene therapy

This study shows that DNase I treatment reduces ecDNA-driven inflammation in MPO-ANCA GN, and gene therapy enhances its therapeutic effect by extending its half-life.

Circulating PD-1hi CXCR5- and CXCR5+ CD4 T cells are elevated in patients with newly diagnosed Giant Cell Arteritis and predict relapse

The paper examines circulating PD-1hi CXCR5- and CXCR5+ CD4 T cells in newly diagnosed GCA patients and finds they predict relapse.

Multi-disease associated risk locus in IL6 represses the anti-inflammatory gene GPNMB through chromatin looping and recruiting MEF2-HDAC complex

The paper identifies a risk locus in IL6 that represses GPNMB via chromatin looping and MEF2-HDAC complex recruitment, linking it to disease susceptibility and immune responses.

Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent Giant Cell Arteritis

This study identifies transcriptomic biomarkers in CD4+ and CD8+ T cells from GCA patients over 12 months, revealing gene-phenotype associations and potential prognostic indicators.