Lu Lu

An emerging PB2-627 polymorphism increases the pandemic potential of avian influenza virus by breaking through ANP32 host restriction in mammalian and avian hosts

This paper identifies a PB2-627V mutation in avian influenza viruses that enhances pandemic potential by overcoming host restriction through ANP32A proteins in both avian and mammalian hosts.

Genetic reassortment and diversification of host specificity have driven evolutionary trajectories of lineages of panzootic H5N1 influenza

The Winners Take It All? Global Evolutionary Success ofH5Nx Reassortants in the 2020-2024 Panzootic

This study identifies 209 H5Nx reassortant strains of avian influenza viruses from 2020-2024, showing that reassortants from Europe had greater host range and persistence than those from Asia.

Treatment of anti-myeloperoxidase glomerulonephritis using recombinant deoxyribonuclease I is enhanced by adeno-associated virus gene therapy

This study shows that DNase I treatment reduces ecDNA-driven inflammation in MPO-ANCA GN, and gene therapy enhances its therapeutic effect by extending its half-life.