Vasculitis and related conditions

Double-Negative B Cell Expansion Defines a Relapse-Prone Immunophenotype in Newly Diagnosed Giant Cell Arteritis

The paper identifies expanded CD27-IgD-double-negative B cells as a biomarker for relapse in newly diagnosed giant cell arteritis.

Spatial transcriptomics reveals injury responsive compartments and coordinated immune fibrotic signaling in ANCA associated renal vasculitis

This study uses spatial transcriptomics to identify disease-responsive compartments and immune-fibrotic signaling in AAV kidney biopsies, linking them to histopathology and fibrotic injury.

Unconventional presentation of an immunodominant HLA-DR15-restricted nephritogenic proteinase 3 epitope implicated in vasculitis

The paper identifies a novel HLA-DR15-restricted CD4 T cell epitope from PR3 associated with vasculitis and describes its unconventional presentation mechanism.

Genome-Wide Association Study of Risk for Eosinophilic Granulomatosis with Polyangiitis

This study identifies two genome-wide significant genetic associations with EGPA, one in SSH2 and one in RUNX1, and shows colocalization with molecular traits related to IL5RA and LYN.

Varicella-zoster virus (VZV)-human interacting proteins enable the clustering of giant cell arteritis (GCA) samples: supports the association of VZV with a subset of GCA cases

The paper investigates the association between VZV and GCA by analyzing proteomics and transcriptomics data, finding that VZV-human interacting proteins cluster GCA samples more effectively than random sets.

Treatment of anti-myeloperoxidase glomerulonephritis using recombinant deoxyribonuclease I is enhanced by adeno-associated virus gene therapy

This study shows that DNase I treatment reduces ecDNA-driven inflammation in MPO-ANCA GN, and gene therapy enhances its therapeutic effect by extending its half-life.

Genome-wide DNA methylation study reveals specific signatures in the affected arterial tissue of giant cell arteritis patients

This study identifies DNA methylation signatures in GCA-affected arterial tissue, revealing disrupted inflammatory pathways and T cell exhaustion markers.

Circulating PD-1hi CXCR5- and CXCR5+ CD4 T cells are elevated in patients with newly diagnosed Giant Cell Arteritis and predict relapse

The paper examines circulating PD-1hi CXCR5- and CXCR5+ CD4 T cells in newly diagnosed GCA patients and finds they predict relapse.

A macrophage-smooth muscle cell axis influences vascular remodeling through activation of the EGFR pathway in giant cell arteritis

Exploration of the circulating human secretome through protein quantitative trait analysis identifies an association between circulating levels of apolipoprotein L1 and risk of giant cell arteritis

This paper identifies a protective association between apolipoprotein L1 polygenic risk scores and reduced risk of giant cell arteritis, supported by Mendelian randomization and pathway analysis.

Multi-disease associated risk locus in IL6 represses the anti-inflammatory gene GPNMB through chromatin looping and recruiting MEF2-HDAC complex

The paper identifies a risk locus in IL6 that represses GPNMB via chromatin looping and MEF2-HDAC complex recruitment, linking it to disease susceptibility and immune responses.

Genetically distinct clinical subsets, and associations with asthma and eosinophil abundance, within Eosinophilic Granulomatosis with Polyangiitis

This study identifies genetic subsets of EGPA associated with asthma and eosinophil levels, revealing two distinct clinical and genetic syndromes.

Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent Giant Cell Arteritis

This study identifies transcriptomic biomarkers in CD4+ and CD8+ T cells from GCA patients over 12 months, revealing gene-phenotype associations and potential prognostic indicators.