Forensic and Genetic Research

This paper detects widespread directional selection in ancient DNA data, identifying 347 genome-wide significant loci and linking them to traits like body fat, skin color, and cognitive performance.

This study analyzes soil adhered to human remains to recover environmental DNA and proteins, revealing microbial, animal, plant, and human genetic information from Neolithic to Medieval sites in England.

This study uses Y chromosome STR variation from Indian and Eurasian males to show that Neolithic agricultural expansion shaped the male gene pool, with haplogroups F, L, and R1a associated with hunter-gatherer, agricultural, and priestly groups respectively.

This study simulates genetic ancestry in small populations, showing that genetic ancestors grow more slowly than genealogical ancestors and that ROHs are common due to genetic drift.

This study uses Y-chromosomal microsatellites to detect founder effects in the Faroe Islands and Iceland, finding distinct paternal genetic structures with no post-founder admixture between the two groups.

Mispitools provides statistical methods for kinship inference in missing persons searches by integrating diverse evidence types and computing likelihood ratios.

The paper identifies and evaluates ancestry informative markers (AIMs) for the Middle East using whole-genome sequencing data and a deep learning tool for ancestry visualization.

This study presents high-coverage genomes from Yayoi and Jomon individuals, revealing genetic differences and dietary adaptations linked to agricultural practices in ancient Japan.

This study develops a random forest classifier to identify body fluids from complex crime scene stains using microbiome data, achieving an F1 score of 0.89 on forensic samples.

Low-ABC improves demographic inference from low-coverage whole-genome data by using genotype likelihoods instead of called genotypes, enabling reliable analysis of population history.

This study uses whole-genome sequencing and machine learning to reconstruct demographic history and gene-flow patterns among African populations, finding that tree-like histories with gene-flow pulses better explain genetic diversity than continuous gene-flow.

RFMix-reader efficiently processes large RFMix output files for local ancestry studies, improving computational efficiency and memory usage.

The paper shows that reference bias causes branch length variation in Y chromosome phylogeny and proposes masking fast-evolving regions to improve accuracy.

AEon estimates global genetic ancestry from VCF/BCF files, offering faster and more accurate results than ADMIXTURE with built-in reference populations and visualization tools.

This study analyzes ancient DNA from the South Caucasus over 5000 years, showing genetic continuity despite high mobility and admixture from Anatolia, the steppe, and southern populations.

This paper develops new likelihood ratio models for DNA phenotyping in forensic investigations and introduces an R package for their application.

The paper estimates the demographic history of the Jomon people using complete mitogenomes, revealing an effective population size increase during the Incipient-Initial phase not seen in present-day Japanese populations.

This study evaluates the effectiveness of the Twist Ancient DNA reagent for enriching ancient human SNPs, finding it robust for up to 27% endogenous DNA content with two rounds of enrichment.

The paper corrects biases in relationship estimation by redefining likelihood models and accounting for multiple common ancestors, extending detectable relationships beyond 10 degrees.

The paper reviews SNP assays for disaster victim identification, evaluates their kinship prediction potential, cost, and throughput, and provides guidance for forensic laboratories.

ASAP uses PCA and NNLS to reliably estimate ancestry in admixed individuals, even with high missing data, and performs faster than existing tools.

This study models the Neolithic expansion in Europe, finding limited cultural transmission and predominant within-group mating, challenging assumptions about demic diffusion.

This study analyzes mitochondrial and Y-chromosome haplogroups in the Iranian population using whole-exome sequencing and SNP microarray data from 18,184 individuals, revealing patterns of genetic diversity and haplogroup distribution.

This paper uses ancient genomes to trace the spread of Germanic languages in Europe, identifying a Baltic origin and migration patterns that challenge traditional timelines.

HaploSight identifies Y chromosomal haplogroups using informative SNPs from a reference phylogenetic tree, achieving high accuracy and compatibility with multiple genotyping arrays.

The paper introduces the ROUA Database, a resource containing whole genome sequences from 300 individuals in Ukraine and Romania, aimed at enhancing understanding of Central European genetic diversity.

This study analyzes 2,762 whole genome sequences from diverse Indian populations to reconstruct 50,000 years of evolutionary history, revealing major admixture events and archaic hominin gene flow.

This study genotypes 80 Ladakh individuals to analyze genetic lineages, admixture, and adaptation, finding distinct East Asian and Indo-European affinities with signals of high-altitude and immunity adaptation.

READv2 improves ancient DNA relatedness analysis by being faster, more accurate, and easier to use than previous methods.

This paper introduces PSMC+, an extension of the PSMC algorithm that accounts for background selection in demographic inference, improving accuracy in effective population size estimation.