Nanoplatforms for cancer theranostics

Converting Lysosomes into Photothermal Organelles Enables Nanoparticle-Free Tumor Ablation via Intracellular Vapor Bubbles

This paper demonstrates nanoparticle-free tumor ablation using lysosomal entrapment of dyes to generate vapor bubbles under laser light.

Architecture-Dependent Stability, Cellular Uptake, and Redox Modulation of Poly(p-Coumaric Acid) Hybrid Nanoparticles for Ovarian Carcinoma Intervention

This paper develops hybrid nanoparticles with improved stability and redox activity for ovarian cancer treatment and imaging.

Artemisinin-Conjugated Phototheranostic Probe for Golgi-Targeted H2O2 Detection and Side Effect Attenuation

This paper develops a phototheranostic probe for detecting H2O2 in the Golgi apparatus and reduces side effects of artemisinin.

Fucoidan-Copper Nanoparticles to Potentiate Synergistic Cancer Cell Cuproptosis and Immunotherapy

This study develops fucoidan-copper nanoparticles that induce cuproptosis and enhance antitumor immunity in liver cancer cells.

Cation-exchange synthesized Zn-doped Ag2S Nanostructures for Photothermal and Photodynamic Therapies across Breast Cancer Subtypes

This paper develops Zn-doped Ag2S nanostructures for photothermal and photodynamic cancer therapy, showing enhanced red-light conversion efficiency and ROS generation across breast cancer subtypes.

Biomimetic porous silicon for rationally engineered combination therapy to induce immunogenic cell death

This study identifies JQ1 and 45°C as optimal components for a combined chemo-photothermal therapy to induce immunogenic cell death in metastatic breast cancer.

MPI-Guided Photothermal Therapy of Prostate Cancer using Stem Cell Delivery of Magnetotheranostic Nanoflowers

This study uses stem cells to deliver magnetic nanoflowers for targeted photothermal therapy, improving tumor retention and enabling MPI-guided ablation with no recurrence.

Hyaluronic Acid-Modified Mesoporous Manganese Dioxide Combined with Carboplatin Synergistically Enhances Ovarian Cancer Therapy

This study develops CBP@HMnO2@HA nanoparticles that combine chemotherapy and chemodynamic therapy, enhancing ovarian cancer treatment by inducing immunogenic cell death and targeting tumors.

Genetically Engineered Cell Membrane-Coated Nanodrug for Targeted Treatment of Thyroid Cancer

This study develops a nanodrug, mPDS@CAR-M, for targeted treatment of RAIR-DTC by combining chemotherapy, photothermal therapy, and tumor cell membrane coating to enhance tumor targeting and therapeutic efficacy.

Nanochirality-programmed Type-I photosensitizer enables deep-tumor photodynamic therapy by reducing extracellular-matrix adhesion

This paper develops a nanochirality-programmed photosensitizer for deep-tumor PDT by enhancing ROS production and reducing matrix adhesion.

Development of Folic Acid-Conjugated Iron Oxide Nanoparticles Loaded with Doxorubicin via Arc Discharge: A Novel Approach for Synergistic Photothermal-Chemotherapy of Cancer Using Bacterial Cellulose-Polyvinyl Alcohol Hydrogel

This paper develops a hydrogel system combining folic acid-conjugated iron oxide nanoparticles loaded with doxorubicin for synergistic chemo-photothermal cancer therapy.

Nanoparticles use magnetoelectricity to target and eradicate cancer cells

This paper demonstrates that magnetoelectric nanoparticles (MENPs) can target and kill cancer cells via irreversible electroporation when activated by MRI, showing significant tumor volume reduction with no toxicities.

AND-gate fluorescence prodrug of the self-immolative delivery for overcoming multidrug resistance

This paper develops a fluorescence prodrug that targets the Golgi and detects H2O2 in inflamed tissues, improving drug delivery and reducing leakage.

Harnessing Dye-induced Photothermal Confinement in Lipid Membranes: A Path to NIR-modulated Artificial Synaptic Vesicles

The paper demonstrates NIR laser-induced release of acetylcholine from VPc-embedded liposomes, causing Ca2+ flux in biospecimens.

Bioinspired Bimetallic Ions Functionalized MOF SAzyme Nanocomposites for Synergistic Ferroptosis/Cuproptosis-Enhanced Immune Checkpoint Therapy

This paper develops a nanocomposite that enhances immune checkpoint therapy by inducing ferroptosis and cuproptosis in cancer cells and modulating the tumor microenvironment.

Magnetite Nanoparticle Photothermal Therapy in a Pancreatic Tumor-on-Chip: A Dual-Action Approach Targeting Cancer Cells and their Microenvironment

This paper applies magnetite nanoparticle photothermal therapy in a pancreatic tumor-on-chip model to target cancer cells and their microenvironment, showing increased cell death and matrix changes.

Noninvasively real-time monitoring in-vivo immune cell and tumor cell interaction by NIR-II nanosensor

This study develops a NIR-II nanosensor to monitor immune-tumor interactions in real-time, showing early cancer cell apoptosis after NK-92 cell treatment.

Oxygen-releasing nanodroplets relieve intratumoral hypoxia in head and neck cancer spheroids.

This study shows that oxygen-releasing nanodroplets reduce hypoxia in head and neck cancer spheroids by delivering oxygen and a photosensitizer, improving therapeutic outcomes.