Trypanosoma species research and implications

Distinct profiles and antibody production by splenic and lymph node antibody-secreting cells in Trypanosoma cruzi infection

The paper compares splenic and lymph node antibody-secreting cells in Trypanosoma cruzi infection, finding distinct transcriptional, phenotypic, and functional profiles.

Adaptation of Iterative Ultrastructure Expansion Microscopy (iU-ExM) enables high-resolution imaging of the cytoskeleton and subcellular architecture of Trypanosoma cruzi

The paper introduces an optimized iU-ExM protocol for high-resolution imaging of T. cruzi cytoskeletal structures and subcellular architecture using conventional confocal microscopy.

Proteomic mapping of novel tubulin post-translational modifications in Trypanosoma cruzi cytoskeleton

The paper identifies and maps novel tubulin post-translational modifications in Trypanosoma cruzi using proteomic analysis.

AKT-like kinase regulates early steps in the Trypanosoma brucei quorum sensing signalling pathway

This study identifies AKT-like kinase as a regulator of quorum sensing in Trypanosoma brucei, showing its role in differentiation and potential as a therapeutic target.

Anatomy and mechanics of tsetse fly blood feeding

This study examines the anatomy and mechanics of tsetse fly blood feeding, finding that efficient feeding is achieved through subtle adaptations rather than unique structures or forces.

Anti-trypanosomal activity and target validation of the M17 leucyl-aminopeptidase inhibitor DDD00057570 in Trypanosoma cruzi

This study validates the M17 leucyl-aminopeptidase as a drug target in Trypanosoma cruzi and identifies DDD00057570 as a selective inhibitor with a high selectivity index.

RNA-seq analysis of Triatoma gerstaeckeri during mite infestation reveals increased metabolic demand and lower reproductive investment

This study uses RNA-seq to analyze Triatoma gerstaeckeri during mite infestation, finding increased metabolic activity and reduced reproductive investment.

An improved Trypanosoma vivax genome assembly confirms the distinct organisation of its variant antigen repertoire

The paper presents an improved T. vivax genome assembly, revealing distinct VSG gene organization and expression mechanisms compared to T. brucei.