Keith R. Matthews

This study identifies AKT-like kinase as a regulator of quorum sensing in Trypanosoma brucei, showing its role in differentiation and potential as a therapeutic target.

This paper presents a telomere-telomere genome assembly of Trypanosoma congolense, revealing distinct VSG organization and expression mechanisms compared to Trypanosoma brucei.

This study shows that Trypanosoma congolense expresses multiple Variant Surface Glycoprotein genes in single cells, unlike Trypanosoma brucei, which uses monoallelic transcription.

The paper analyzes antigenic variation in Trypanosoma brucei during chronic bovine infections, revealing enhanced diversity and a reproducible temporal expression hierarchy of VSGs.

The paper uses synthetic TALE proteins to identify chromatin-associated proteins on repetitive elements in Trypanosoma brucei, revealing their roles in chromosome structure and function.

vsgseq2 improves the analysis of VSG expression diversity and abundance in Trypanosoma brucei populations using updated bioinformatics tools.

This paper develops a Cas10-based lateral flow assay for detecting 7SL-sRNA in cattle with active trypanosomiasis, showing high sensitivity and specificity during chronic infection phases.

TrAGEDy aligns gene expression trajectories from different biological processes without integration, improving detection of biologically relevant genes in T cells and Trypanosoma brucei.

This study identifies cryptic stumpy-like T. brucei forms in cattle with low parasitaemia, challenging rodent-based assumptions about stumpy form differentiation.

This study identifies molecular changes and reversible steps in the loss of stumpy transmission in monomorphic trypanosomes using genomic analysis and laboratory selection.

This paper identifies TcREG9.1 as a regulator of attachment and morphological development in Trypanosoma congolense, showing its role in surface adhesion and transmission.

The paper identifies the SPARC complex in Trypanosoma brucei, showing it defines RNAPII promoters and regulates transcription start site positioning and directionality.

This paper sequences and compares the genomes of two non-pathogenic trypanosomes to identify genomic features associated with host and vector specificity.

The paper re-analyzes genomic data to define clades of monomorphic Trypanozoon species and identifies lineage-specific variation, challenging traditional classifications and suggesting evolutionary relationships.

The paper identifies chromatin factors in Trypanosoma brucei and their association with transcription initiation and termination sites through proteomic and ChIP-seq analyses.