Wnt/β-catenin signaling in development and cancer

The paper shows that Wg spreads up to eleven cell distances in Drosophila wing epithelium and that cells outside this range rely on Frizzled2 for target gene expression.

The paper shows that aerobic glycolysis increases intracellular pH in tail bud cells, promoting β-catenin acetylation and Wnt signaling, which drives mesodermal fate over neural fate.

The paper models the interaction between p24-GOLD domain and Wnt8, suggesting a lectin-like binding mechanism and potential decoy-like quenching of Wnt signaling.

This study identifies PDI-1 as a key factor in Wnt protein secretion in C. elegans and shows its conserved role in human cells.

The paper shows EGFR is required for Wnt9a-Fzd9b signaling specificity in HSPC development, identifying key domains and phosphorylation events.

This study identifies RAPGEF5 as a regulator of β-catenin nuclear transport through Wnt signaling, independent of canonical import mechanisms.

The paper uses sensitivity analysis on computational models of the Wnt β-catenin transcription complex to explore psychophysical laws and gene-gene interactions in normal and tumor samples.