Wnt/β-catenin signaling in development and cancer

Canonical Wnt induction by OTULIN prevents keratinocyte death and skin inflammation

This study shows OTULIN prevents keratinocyte death and skin inflammation by promoting canonical Wnt signaling through regulation of β-catenin ubiquitination.

Dishevelled-mediated clustering stabilizes Frizzled6 and Vangl2 to establish planar cell polarity in the mammalian skin

The Wnt co-receptor Arrow-LRP5/6 is required for Planar Cell Polarity establishment in Drosophila

This study shows that the Wnt co-receptor Arrow-LRP5/6 is essential for Planar Cell Polarity (PCP) establishment in Drosophila, correcting the previous notion that PCP signaling operates without co-receptors.

Wild-type and mutated beta-catenin differently repress RND3/RHOE expression in hepatocellular carcinoma

This study shows wild-type and mutated beta-catenin differently repress RND3/RHOE expression in hepatocellular carcinoma through distinct mechanisms.

Positive Selection Screen Identifies Natural Product β-Catenin Inactivators

The paper screens natural products to identify β-catenin inactivators, finding one that activates novel PKCs and relocates β-catenin to juxtamembrane vacuolar structures.

WNT-driven immune evasion promotes malignant transformation of BRAF-mutant colorectal cancer

This study shows that WNT signaling enables immune evasion in BRAF-mutant colorectal cancer, promoting tumor progression through changes in T cell phenotypes.

Tissue tension permits β-catenin phosphorylation to drive mesoderm specification in human embryonic stem cells.

The paper shows that tissue tension enables Src-mediated β-catenin phosphorylation, which is critical for mesoderm specification in human embryonic stem cells.

Uncovering Phenotypic Expansion in AXIN2-Related Disorders Using Precision Animal Modeling

The paper identifies novel AXIN2 variants causing expanded phenotypes in humans and validates their pathogenicity using human, mouse, and fly models.

Anticancer synthetic arylsulfonamides with Wnt1-modulating activity

The paper evaluates analogs of MSAB, a Wnt1/{beta}-catenin inhibitor, to determine how ester substitutions affect antiproliferative activity in cancer cell lines.

Axin1 and Axin2 regulate the WNT-signaling landscape to promote distinct mesoderm programs

The paper investigates how Axin1 and Axin2 regulate WNT signaling to specify distinct mesoderm lineages during gastrulation.

Mutational scanning reveals substrate-assisted autoregulation of the WNT destruction complex

The paper systematically maps the sequence-function landscape of the WNT destruction complex using mutational scanning, identifying novel mutations and revealing substrate-assisted autoregulation mechanisms.

Transcriptional feedback targeting Wnt pathway components reveals hidden heterogeneity in C. elegans seam cell lineages.

The paper identifies transcriptional asymmetry in Wnt pathway components during C. elegans seam cell divisions, revealing feedback mechanisms that reinforce cell fate decisions.

Integrin beta 4 promotes colorectal cancer progression by upregulating Ezrin and activating the Wnt/β-catenin signaling pathway

This study identifies ITGB4 as a driver of colorectal cancer progression by upregulating Ezrin and activating the Wnt/β-catenin pathway.

Wnt signaling regulates passive cell competition in the retina by inducing differential cell adhesion

The paper shows that Wnt signaling, through {beta}-catenin, regulates passive cell competition in the retina by inducing a cadherin switch that segregates cells into distinct compartments.

Runx1 and Runx2 act in concert to suppress Wnt/β-catenin-driven mammary tumourigenesis

This study shows that Runx1 and Runx2 suppress Wnt/β-catenin-driven mammary tumourigenesis, with combined loss leading to increased tumour development and oncogenic pathway activation.

Wnt signaling promotes inflammation and EMT-associated gene expression in mesenchymal TNBC

The paper shows that Wnt signaling in mesenchymal TNBC cells increases inflammation and EMT-related gene expression, and identifies a 55-gene signature associated with these effects.

Long-term single molecule localization microscopy uncovers dynamic co-assembly of Lrp6 and Ror2 into Wnt-signalosomes

This study uses single-molecule tracking to show that Lrp6 and Ror2 co-assemble into hybrid Wnt signalosomes dynamically.

APC coordinates GSK3 phosphorylation of SETD8 to suppress colorectal cancer

This study identifies SETD8 as a target of APC-coordinated GSK3 phosphorylation in colorectal cancer, showing that phosphorylation suppresses SETD8's oncogenic activity.

Emergence of cell polarity by reciprocal interactions between Wnt and core PCP components

This study shows that Wnt11 and core PCP components interact reciprocally to establish cell polarity in Xenopus embryos without relying on Wnt gradients.

Discovery of Tankyrase scaffolding inhibitor specifically targeting the ARC4 peptide binding domain

The paper identifies a Tankyrase scaffolding inhibitor, S8 (ARCher-142), that selectively targets the ARC4 peptide binding domain with 8 µM potency.

Identification of Wnt regulated genes that are repressed by, or independent of, β-catenin

The paper identifies Wnt-regulated genes repressed by or independent of β-catenin in a cancer model, revealing a cis-regulatory motif involved in repression.

CD73 restrains mutant β-catenin oncogenic activity in endometrial carcinomas

This paper identifies CD73 as a regulator that limits oncogenic activity of mutant β-catenin in endometrial carcinomas, showing that its loss increases transcriptional activity and tumor progression.

Anti-resonance in developmental signaling regulates cell fate decisions

The paper identifies anti-resonance in Wnt signaling that suppresses mesoderm differentiation in human cells by analyzing signal frequency effects using optogenetics and modeling.

Differential functions of multiple Wnts and receptors in cell polarity regulation in C. elegans

The paper investigates the distinct and cooperative roles of multiple Wnt ligands and receptors in regulating cell polarity orientation in C. elegans.

Mutations within the predicted fragment-binding region of FAM83G/SACK1G abolish its interaction with the Ser/Thr kinase CK1α

The paper identifies mutations in SACK1G that disrupt its interaction with CK1α, using computational modeling and experimental validation.

TNF Receptor 1 regulates colonic mesenchymal cell diversity and the epithelial stem cell niche.

This study shows TNFR1 promotes colonic mesenchymal cell diversity and stem cell niche function, with TNFR1 deficiency reducing cell diversity and impairing stem cell maintenance.

Hepatocellular carcinoma-associated AXIN1 mutations drive low levels of Wnt/β-catenin pathway activity that allow for niche-independent growth and YAP/TAZ signaling

This study shows that AXIN1 mutations in HCC lead to reduced Wnt/β-catenin activity and increased YAP/TAZ signaling, enabling niche-independent growth.

β-Catenin condensation facilitates clustering of the cadherin/catenin complex and formation of nascent cell-cell junctions

This study shows that β-catenin condensation drives the clustering of the cadherin/catenin complex and the formation of new cell-cell junctions.

Structural basis for Porcupine inhibition

This paper presents cryo-EM structures of PORCN with inhibitors, revealing a conserved water-mediated binding mechanism for rational drug design.

Differential Wnt/β-Catenin Signaling via TCF7L2/LEF1 Binding Specificity Shapes Cellular and Tumor Phenotypes

The paper identifies how differential TCF7L2/LEF1 binding specificity of {beta}-catenin shapes distinct gene regulatory outcomes in liver tumors.