Topic · Physiology · Medicine

Telomeres, Telomerase, and Senescence

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

3 papers

Senescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in cancer

Clemens Hinterleitner, Valentin J.A. Barthet, Hailey V. Goldberg, Kristen C. Vogt, Ana Marie Perea, Logan R. Hillger, Stephen B. Ruiz, Domhnall McHugh, Yu-Jui Ho, Almudena Chaves Perez, Maria Skamagki, Sara Flowers, Hannah C. Styers, Natasha Rekhtman, Xueqian Zhuang, , Scott W. Lowe

P-selectin-targeted fucoidan nanoparticles carrying Navitoclax or dBET6 deplete a senescent-like, lipid-associated macrophage subset, reverse mouse liver and lung fibrosis with less toxicity, and restore checkpoint therapy response in fibrotic tumors.

Science · Sep 24, 2026Peer-reviewedCancer Biology✦ In-depth digest

SenSASP: A Unified, Multi-Layer Database of Senescence and SASP Genes

Hao Xuan, Yu Huang, Jiang Bian

Merging CellAge, GenAge, SenMayo and Reactome senescence genes onto Ensembl IDs yields 1,250 provenance-tracked genes, most also annotated with mouse/zebrafish orthologs, tissue expression and STRING interactions.

bioRxiv · Sep 11, 2026 · PreprintBioinformatics✦ In-depth digest

Senolytic treatment with fisetin reverses age-related endothelial dysfunction partially mediated by SASP factor CXCL12

Sophia A. Mahoney, Krystyna Mazan-Mamczarz, Dimitrios Tsitsipatis, Nicholas S. VanDongen, Charnae' Henry-Smith, Ada N. Okereke, Rachel B. Munk, Sanna Darvish, Kevin O. Murray, Supriyo De, Myriam Gorospe, Douglas R. Seals, Matthew J. Rossman, Allison B. Herman, Zachary Stephen Clayton

Single-cell aortic transcriptomics and plasma bioassays in aged mice show that intermittent fisetin treatment clears senescent endothelial cells and reverses endothelial dysfunction partially driven by circulating CXCL12.

Aging Cell · Apr 22, 2026Peer-reviewedPhysiology✦ In-depth digest