Sirtuins and Resveratrol in Medicine

This study identifies SIRT4 as a specific interactor of C-RAF kinase, showing it suppresses MAPK signaling by stabilizing the inactive form of C-RAF.

This study investigates NMN's effects on glucose metabolism, revealing organ-specific mechanisms that improve glucose uptake without relying on mitochondrial biogenesis.

This study identifies NUCKS1 as a novel SIRT7 interactor that promotes chromatin binding during senescence and liver aging, leading to metabolic and inflammatory gene expression.

This study shows that Sirt3 is induced during glucose deprivation and supports synaptic transmission by enhancing mitochondrial function and synaptic vesicle recycling.

This study shows that SIRT2 inhibition reduces cardiac hypertrophy and heart failure in mice by modulating NRF2 activity and antioxidant defenses.

The paper identifies a SIRT6 variant enriched in centenarians that improves genome stability through enhanced mADPr activity and interaction with Lamin A.

This study identifies DLEU2 as a lncRNA that regulates sirtuins and mitochondrial complex IV, linking it to metabolic disorders across generations through maternal diet effects.

This study shows that endurance exercise activates cardiac Nmnat/NAD+/SIR2 pathways in Drosophila, protecting against HFD-induced heart defects but not lifespan reduction.

The paper shows QKI 6 reduces neuronal apoptosis and CIRI by promoting triglyceride synthesis via the SIRT1-PPARγ-PGC-1α pathway in a rat model.