Sirtuins and Resveratrol in Medicine

NAD+ Replenishment Reduces Cardiomyocyte Senescence and Improves Diastolic Function in the Aged Male Heart

This study shows that NAD+ replenishment with NR or NRH reduces cardiomyocyte senescence and improves diastolic function in aged male mice but not females.

NAD metabolism mediates a sex-specific protection against early life infections

This study identifies NAD metabolism as a sex-dependent factor influencing early-life infection outcomes, showing sex-specific effects of NAD precursor supplementation in mice and humans.

Recombinant SIRT1 expression and SIRT1-METTL3 interaction analysis with computational identification of phytochemical SIRT1 activators and inhibitors

This study identifies phytochemical SIRT1 activators and inhibitors through protein expression, purification, and computational modeling, revealing Catechin and Ginsenosides as promising therapeutic candidates.

Photo-downregulation of SIRT4 mitigates aging in mice by enhancing H3K9ac via fatty acid metabolism

This study shows that red light exposure reduces SIRT4 in aged mice, enhancing H3K9ac via fatty acid metabolism and mitigating cellular aging.

A systematic evaluation of SIRT6 as transcriptomic biomarker of aging

This study evaluates SIRT6 as an aging biomarker by analyzing transcriptomic data across species and identifies context-dependent dysregulation in Alzheimer's disease.

NAD+ precursor treatment prevents cardiomyopathybut disrupts erythroid maturation in mitochondrial progeria

This study shows that NAD+ precursor treatment improves cardiac function but worsens erythroid maturation in mitochondrial progeria, highlighting tissue-specific effects of NAD+ boosting.

Dynamics of blood NAD and glutathione in health, disease, aging and under NAD-booster treatment

The paper measures NAD and glutathione levels in blood across health, disease, aging, and NAD-boosting treatment, finding age-independent normal distributions and disease-specific redox fingerprints.

Tyrosine phosphorylation and dimerization cooperatively activate NAMPT to enable NAD+ synthesis in cancer

This study identifies tyrosine phosphorylation and dimerization as cooperative mechanisms activating NAMPT, enhancing NAD+ synthesis and cancer cell growth.

NAMPT activation uncovers a senescence-specific vulnerability and promotes healthy aging in combination with NAM

This paper identifies a strategy combining NAMPT activation and NAM supplementation to target NAD+ dysregulation and senescent cells, promoting healthy aging in mice.

Activation of the NAD⁺-Sirtuin Axis Protects Against Chronic Doxorubicin-Induced Subclinical Renal Tubular Injury Through Restoration of Mitochondrial Homeostasis and Suppression of Inflammation

This study shows that chronic low-dose doxorubicin causes mitochondrial dysfunction and inflammation in renal tubules, which can be mitigated by activating the NAD⁺-Sirtuin axis with resveratrol or NMN.

The Effects of Phosphorylation on the Structure and Function of Motif A, an Intrinsically Disordered Region within SIRT1

This study investigates how phosphorylation affects the structure and function of motif A in SIRT1, showing that phosphomimetic mutation at Ser27 enhances SIRT1 activity and induces structural ordering of the disordered region.

The divergent effects of nicotinamide riboside and high-intensity exercise training on skeletal muscle epigenetic aging

This study examines how NR supplementation and HIIT affect skeletal muscle epigenetic aging, finding opposing effects on epigenetic age acceleration across different clocks.

The Nicotinamide Salvage Pathway is a Metabolic Vulnerability of High-Risk MDS Stem Cells

This study identifies NAMPT as a metabolic vulnerability in HR-MDS HSPCs, showing its inhibition reduces their survival and disease burden.

Spatiotemporal biosensor profiling reveals an autonomous mitochondrial NAD+/NMN regulatory network centered on NMNAT3

The paper develops biosensors to study NAD+ and NMN dynamics in subcellular compartments and identifies a mitochondrial regulatory network involving NMNAT3.

Conserved Transcriptomic Signatures of Sirt6 Activity: A Cross-Species RNA-seq Meta-analysis

This study performs a cross-species RNA-seq meta-analysis to identify conserved and novel gene expression changes associated with Sirt6 perturbation in mammals and Drosophila.

Revisiting p53:Sirt1 interaction in the light of controlling p53 acetylation levels

This study presents the first structural model of the full-length p53:Sirt1 complex, showing Sirt1 selectively deacetylates p53 at K582 and binds acetylated p53 with a 1:1 stoichiometry.

Long-lived mammals contain more phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and resistance to oxidative stress

This study identifies phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and oxidative stress resistance, correlating with maximum lifespan in mammals.

SIRT5-dependent regulation of ASL controls arginine metabolism and T cell function

This study identifies SIRT5 as a key regulator of arginine metabolism and T cell function through its interaction with ASL, showing that SIRT5 depletion reduces anti-inflammatory effects of NAD+ precursors.

Oral LNAD+ Rapidly Elevates Intracellular NAD and Metabolic Flux Without Elevating Circulating NAD: Evidence from a Randomized Controlled Trial

This paper reports that oral LNAD+ rapidly increases intracellular NAD without elevating circulating NAD, showing compartment-specific effects and safety in a clinical trial.

A High-throughput Fluorescence Polarization Assay for Screening Sirtuin Inhibitors

The paper develops a high-throughput fluorescence polarization assay to screen SIRT1-3 inhibitors, showing improved efficiency and performance compared to existing methods.

SIRT5 acts in the tumor microenvironment via endothelial cell metabolism to support breast cancer growth

This study identifies SIRT5 as a regulator of endothelial cell metabolism in the tumor microenvironment, showing its role in supporting breast cancer growth through vascular function.

Mapping Evidence Gap Between NMN and NR for Metabolic Outcomes: A Systematic Review, Transitivity Assessment, and Indirect Comparison Meta-Analysis

This paper systematically reviews NMN and NR trials, assesses transitivity, and performs indirect comparisons, finding structural limitations prevent reliable comparison of their metabolic effects.

Effects of NAD⁺ Repletion with Nicotinamide Riboside on Obesity-Induced Chronic Kidney Disease and Renal Cell Lipotoxicity

This study investigates the effects of nicotinamide riboside (NR) on obesity-induced chronic kidney disease and renal cell lipotoxicity in mice, finding antioxidant and mitochondrial benefits in vitro but no metabolic protection in vivo.

Structural and biochemical characterization of a novel inhibitor of NMNAT1, the gatekeeper of nuclear NAD+ biosynthesis

The paper identifies AMI-1 as an inhibitor of NMNAT1, shows its effect on NAD+ levels and cancer cell viability, and determines its binding mechanism via cryo-EM.

Multi-omics characterization of SIRT3 metabolism and its adaptation to the presence of amyloid-beta oligomers in nasal epithelial cells

The paper investigates the role of SIRT3 in nasal epithelial cell metabolism under amyloid-beta oligomer exposure using multi-omic approaches and identifies sex-dependent SIRT protein level differences in neurological disorders.

Aging in Fast-Forward: An Inducible SIRT6 Deficiency model as a Lens on Brain Aging and Neurodegeneration

This paper develops a reversible SIRT6 deficiency model to study brain aging and neurodegeneration, finding transcriptomic changes resembling aging and Alzheimer's disease.

Balance between DNA repair, LINE1 suppression and lifespan in mice with SIRT6 Serine 10 mutations

This study shows that SIRT6 Serine 10 mutations in mice affect DNA repair, LINE1 expression, and lifespan, with reduced LINE1 control having a stronger impact on lifespan than enhanced DNA repair.

A proteomic study of the dual oncogenic and tumor- suppressive roles of SIRT3 in lung and breast cancer cell lines

This study investigates how SIRT3 inhibition affects proteomic and acetylomic profiles in lung and breast cancer cell lines, revealing context-dependent metabolic responses.

Sirtuin 3 with rs11607019 regulates gene expression in 293 cells

The paper investigates the transcriptional effects of rs11607019 on gene expression in 293 cells, finding it upregulates several genes and downregulates APOBEC3G.

Beyond Cell Cycle Control: CDKN2A Loss Orchestrates NAD⁺ Metabolic Plasticity and NAMPT Inhibitor Sensitivity in Glioblastoma

The paper shows CDKN2A loss in glioblastoma affects NAD+ metabolism and increases sensitivity to NAMPT inhibitors, beyond its role in cell cycle control.