Sirtuins and Resveratrol in Medicine

NAD metabolism mediates a sex-specific protection against early life infections

This study identifies NAD metabolism as a sex-dependent factor influencing early-life infection outcomes, showing sex-specific effects of NAD precursor supplementation in mice and humans.

Recombinant SIRT1 expression and SIRT1-METTL3 interaction analysis with computational identification of phytochemical SIRT1 activators and inhibitors

This study identifies phytochemical SIRT1 activators and inhibitors through protein expression, purification, and computational modeling, revealing Catechin and Ginsenosides as promising therapeutic candidates.

A systematic evaluation of SIRT6 as transcriptomic biomarker of aging

This study evaluates SIRT6 as an aging biomarker by analyzing transcriptomic data across species and identifies context-dependent dysregulation in Alzheimer's disease.

Tyrosine phosphorylation and dimerization cooperatively activate NAMPT to enable NAD+ synthesis in cancer

This study identifies tyrosine phosphorylation and dimerization as cooperative mechanisms activating NAMPT, enhancing NAD+ synthesis and cancer cell growth.

NAMPT activation uncovers a senescence-specific vulnerability and promotes healthy aging in combination with NAM

This paper identifies a strategy combining NAMPT activation and NAM supplementation to target NAD+ dysregulation and senescent cells, promoting healthy aging in mice.

Activation of the NAD⁺-Sirtuin Axis Protects Against Chronic Doxorubicin-Induced Subclinical Renal Tubular Injury Through Restoration of Mitochondrial Homeostasis and Suppression of Inflammation

This study shows that chronic low-dose doxorubicin causes mitochondrial dysfunction and inflammation in renal tubules, which can be mitigated by activating the NAD⁺-Sirtuin axis with resveratrol or NMN.

Spatiotemporal biosensor profiling reveals an autonomous mitochondrial NAD+/NMN regulatory network centered on NMNAT3

The paper develops biosensors to study NAD+ and NMN dynamics in subcellular compartments and identifies a mitochondrial regulatory network involving NMNAT3.

Conserved Transcriptomic Signatures of Sirt6 Activity: A Cross-Species RNA-seq Meta-analysis

This study performs a cross-species RNA-seq meta-analysis to identify conserved and novel gene expression changes associated with Sirt6 perturbation in mammals and Drosophila.

SIRT5-dependent regulation of ASL controls arginine metabolism and T cell function

This study identifies SIRT5 as a key regulator of arginine metabolism and T cell function through its interaction with ASL, showing that SIRT5 depletion reduces anti-inflammatory effects of NAD+ precursors.

Oral LNAD+ Rapidly Elevates Intracellular NAD and Metabolic Flux Without Elevating Circulating NAD: Evidence from a Randomized Controlled Trial

This paper reports that oral LNAD+ rapidly increases intracellular NAD without elevating circulating NAD, showing compartment-specific effects and safety in a clinical trial.

SIRT5 acts in the tumor microenvironment via endothelial cell metabolism to support breast cancer growth

This study identifies SIRT5 as a regulator of endothelial cell metabolism in the tumor microenvironment, showing its role in supporting breast cancer growth through vascular function.

Mapping Evidence Gap Between NMN and NR for Metabolic Outcomes: A Systematic Review, Transitivity Assessment, and Indirect Comparison Meta-Analysis

This paper systematically reviews NMN and NR trials, assesses transitivity, and performs indirect comparisons, finding structural limitations prevent reliable comparison of their metabolic effects.

Structural and biochemical characterization of a novel inhibitor of NMNAT1, the gatekeeper of nuclear NAD+ biosynthesis

The paper identifies AMI-1 as an inhibitor of NMNAT1, shows its effect on NAD+ levels and cancer cell viability, and determines its binding mechanism via cryo-EM.

Multi-omics characterization of SIRT3 metabolism and its adaptation to the presence of amyloid-beta oligomers in nasal epithelial cells

The paper investigates the role of SIRT3 in nasal epithelial cell metabolism under amyloid-beta oligomer exposure using multi-omic approaches and identifies sex-dependent SIRT protein level differences in neurological disorders.

Aging in Fast-Forward: An Inducible SIRT6 Deficiency model as a Lens on Brain Aging and Neurodegeneration

This paper develops a reversible SIRT6 deficiency model to study brain aging and neurodegeneration, finding transcriptomic changes resembling aging and Alzheimer's disease.

Balance between DNA repair, LINE1 suppression and lifespan in mice with SIRT6 Serine 10 mutations

This study shows that SIRT6 Serine 10 mutations in mice affect DNA repair, LINE1 expression, and lifespan, with reduced LINE1 control having a stronger impact on lifespan than enhanced DNA repair.

Sirtuin 3 with rs11607019 regulates gene expression in 293 cells

The paper investigates the transcriptional effects of rs11607019 on gene expression in 293 cells, finding it upregulates several genes and downregulates APOBEC3G.

Beyond Cell Cycle Control: CDKN2A Loss Orchestrates NAD⁺ Metabolic Plasticity and NAMPT Inhibitor Sensitivity in Glioblastoma

The paper shows CDKN2A loss in glioblastoma affects NAD+ metabolism and increases sensitivity to NAMPT inhibitors, beyond its role in cell cycle control.

Transcriptional Profiling of D1-MSNs Reveals SIRT1-Dependent and -Independent Responses to Chronic Social Defeat Stress

This study uses cell-type-specific transcriptomics to show that SIRT1 modulates depression susceptibility in D1-MSNs through metabolic and circadian pathways under chronic social defeat stress.

Adipose Tissue Overexpression of Nicotinamide Phosphoribosyltransferase Prevents Metabolic Dysfunction in Obese Mice

This study shows that overexpressing NAMPT in adipocytes protects against metabolic dysfunction in male obese mice but not females, via improved interorgan communication and extracellular vesicle effects.

Rare centenarian SIRT6 coding variants elevate SIRT6 protein levels and resist cellular senescence

The paper identifies rare SIRT6 variants in centenarians that increase protein levels and delay cellular senescence, offering insights for geroprotective therapies.

Rewired NAD+ metabolism promotes NF-κB-mediated oxidative stress and disrupts lipid homeostasis in liver fibrosis progression

This study identifies NAD+ metabolism rewiring as a key driver of oxidative stress and lipid dysregulation in liver fibrosis progression using multi-omics analyses in a mouse model.

NAD+ boosting by oral nicotinamide mononucleotide administration regulates key metabolic and immune pathways through SIRT1 dependent and independent mechanisms to mitigate diet-induced obesity and dyslipidemia in mice.

SIRT1-IDR-Driven Temporal Gating of Sequential Transcription-Factor Recruitment Coordinates Fasting Adaptation

The paper identifies the SIRT1 IDR as a temporal gate for sequential TF recruitment during fasting, showing its role in metabolic adaptation.

SIRT4 Controls Macrophage Function and Wound Healing through Control of Protein Itaconylation in Mice

This study identifies SIRT4 as a lysine deitaconylase that regulates macrophage inflammatory responses and wound healing by modulating protein itaconylation in mice.

NAD+ reduction in glutamatergic neurons triggers fatty acid catabolism and neuroinflammation in the brain, mitigated by SARM1 deletion

The paper shows that loss of NMNAT2 in glutamatergic neurons causes metabolic shifts and neurodegeneration, which are mitigated by SARM1 deletion.

Non-DNA-damaging DNA-PK activation improving hearing and prolonging life due to NAD+ and SIRT upregulation

This paper shows that MA-5 improves hearing loss and extends lifespan in mice by increasing NAD+ and SIRT1 through DNA-PK activation and mitochondrial function.

The mitochondrial NAD transporter SLC25A51 is a modulator of beta cell senescence and type 2 diabetes

This study identifies SLC25A51 as a modulator of beta-cell senescence and type 2 diabetes by affecting NAD+ homeostasis and metabolic control.

Sirtuin 2 controls global protein synthesis by regulating Rheb-GTPase

This study identifies SIRT2 as a regulator of global protein synthesis by modulating Rheb-GTPase activity, showing its potential as a therapeutic target for diseases with increased protein synthesis.

SIRT6 activator fucoidan extends healthspan and lifespan in aged wild-type mice

This study shows that fucoidan, a seaweed-derived polysaccharide, extends healthspan and lifespan in aged mice by activating SIRT6, which reduces LINE1 retrotransposon activity and epigenetic aging.