Immune cells in cancer

This study identifies granulocyte-derived lipids loaded on HDLs as essential for IL-4-induced M2 macrophage activation and oxidative phosphorylation.

This study shows that AGuIX nanoparticles and their combination with ionizing radiation induce proinflammatory reprogramming of tumor-associated macrophages via AMPK-dependent mitochondrial fragmentation.

This study identifies distinct TNF-dependent aging signatures in monocyte subpopulations, showing that aging affects their transcriptional regulation differently.

This study identifies spatial localization as a key determinant of macrophage heterogeneity and self-renewal in breast cancer, with implications for therapeutic strategies.

This study shows that androgen blockade increases NLRP3 in macrophages, which when combined with NLRP3 agonist, enhances cancer cell phagocytosis and tumor control in a mouse model of prostate cancer.

The paper refines a gene signature for identifying TAM polarization in CRC using single-cell RNA-seq and transfer learning, validated across multiple datasets.

The paper identifies two neutrophil subtypes in cancer using single-cell RNA sequencing, showing their conservation across species and tumor types, and links them to immunosuppressive pathways.

This study compares proliferation and tolerance in tissue-resident and recruited macrophages using single-cell RNA sequencing, finding that proliferative capacity differs between cell types.

This study identifies biological processes and molecules differentiating M1 and M2 macrophages using RNA-seq data from mouse samples.

The paper identifies three regulatory factors that shift macrophage polarization from M1 to M2 and increase susceptibility to S. aureus infection.

The paper builds a Boolean model to simulate macrophage polarization in an in-vitro chronic lymphocytic leukaemia model, revealing the formation of tumour-associated macrophages.