Immune cells in cancer

Mesaconate-Based Polyester Nanoparticles Reveal How Metabolite Isomerism Shapes Polymer Behavior, Macrophage Reprogramming, and Systemic Immunomodulation

This study creates mesaconate-based polyester nanoparticles that show different immunomodulatory effects in macrophages and improve survival in endotoxemia.

Small-molecule ACOD1 inhibition attenuates colitis and tumor growth through a shared myeloid mechanism, diverging from genetic deletion

This study shows that ACOD1 inhibition reduces colitis and tumor growth via a shared myeloid mechanism, differing from genetic deletion effects.

Genetic and Pharmacologic Targeting of Eya3 in Macrophages Drives Anti-Tumor Immunity in Triple-Negative Breast Cancer

This study identifies Eya3 in macrophages as a checkpoint for anti-tumor immunity in TNBC, showing that its depletion or inhibition enhances immune responses and reduces tumor growth.

Stemness overcomes IFNγ-induced antitumour exhaustion in human macrophages

This study shows that inducing stemness in human macrophages prevents IFNγ-induced exhaustion, enhancing their antitumour activity and persistence in vivo.

Neutrophils orchestrate pre-metastatic immunosuppressive bone marrow remodeling during prostate cancer metastasis

This study identifies IGF1R-dependent neutrophil reprogramming in the bone marrow microenvironment during prostate cancer metastasis and shows its therapeutic targeting potential.

Age-associated transcriptional programs in tumor-associated macrophages are associated with tumor progression in HPV-negative oral cancer

The paper identifies age- and smoking-associated SPP1high tumor-associated macrophages in HPV-negative oral cancer that promote tumor progression by remodeling the extracellular matrix and suppressing antitumor immunity.

RORγ Inverse Agonism Redirects Tumour-Conditioned Emergency Myelopoiesis and Attenuates Established Tumour Progression

This study shows that RORγ inverse agonism reduces tumor progression by altering myeloid cell organization and immune responses in gastroesophageal adenocarcinoma.

CRISPR-Cas9 Editing of Myeloid Lectins Reveals Target-Dependent Transcriptional Remodeling in Tumor-Associated Macrophages

This study uses CRISPR-Cas9 to perturb myeloid lectins in macrophages, revealing target-specific transcriptional changes and immunometabolic reprogramming in tumor-associated macrophages.

Radiotherapy-induced vascular dysfunction alters neutrophil phenotype to promote tumor cell colonization of mammary adipose tissue

This study shows that radiotherapy-induced vascular dysfunction leads to neutrophil activation and tumor cell colonization in mammary adipose tissue in lymphocyte-deficient mice.

Alternatively polarized neutrophils metabolically restrain macrophage-driven inflammation

This study identifies an arginine-dependent metabolic mechanism by which alternatively polarized neutrophils restrain macrophage-driven inflammation in mouse models and human diseases.

Folate metabolism in tumor-associated macrophages drives immunosuppressive function to promote tumor growth

This study identifies folate receptor beta (FRβ) as a metabolic checkpoint on tumor-associated macrophages (TAMs) that promotes immunosuppression and tumor growth.

Disruption of the ARID1A-containing SWI/SNF complex reprograms tumor-associated macrophages and enhances immunotherapy response

This study shows that disrupting the ARID1A-containing SWI/SNF complex in tumor-associated macrophages enhances immunotherapy response by reprogramming their gene expression and improving checkpoint blockade efficacy.

A druggable chromatin vulnerability in suppressive neutrophils restores antitumor immunity

This paper identifies a druggable chromatin vulnerability in suppressive neutrophils that can restore antitumor immunity through mSWI/SNF antagonists.

CCR4+low-density neutrophils define a novel immunosuppressive subset associated with breast cancer progression and early mortality

The paper identifies a novel immunosuppressive neutrophil subset, CCR4+LDN, associated with breast cancer progression and mortality, and shows its potential as a biomarker and therapeutic target.

A cell death screen identifies macrophage-depleting agents with therapeutic potential

This study identifies three small molecule inhibitors that reduce macrophage survival and viability, showing therapeutic potential in models of inflammation and cancer.

Dual Immunoliposome Targeting of PD-L1 and CSF1R affects T-Cell readouts in tumor-conditioned co-cultures: An In Vitro Study in Glioblastoma and Medulloblastoma

This study evaluates dual immunoliposome targeting of PD-L1 and CSF1R in tumor-conditioned co-cultures, showing enhanced T-cell responses in glioblastoma and medulloblastoma models.

High-resolution CRISPR/Cas9 screens identify PAK2 as a suppressor of macrophage proliferation

The paper uses CRISPR/Cas9 screens to identify PAK2 as a suppressor of macrophage proliferation in murine bone marrow-derived macrophages.

A Latent Inflammatory Tissue-State Variable Mechanistically Links Radiotherapy-Induced Immune Remodeling to Recurrent Tumor Permissiveness

The paper develops an agent-based model to show that unresolved inflammation after radiotherapy creates a tissue state that promotes tumor recurrence.

Single-cell proteomics maps circulating monocyte dynamics in advanced head and neck squamous cell carcinoma

The paper uses single-cell proteomics to analyze circulating immune cells in HNSCC patients, revealing proteomic changes in monocytes during metastasis.

Longitudinal proteomic module profiles vary across human monocyte differentiation and polarization conditions

In reanalyzed PXD016245 monocyte-differentiation proteomes, eight predefined protein-module scores retain a joint condition association (incremental R^2 0.313663, permutation p = 0.0002) beyond source block and day.

Myeloid Lectin Profiling Identifies SYK as a Targetable Signaling Node for Remodeling Immunosuppressive Tumor-Associated Macrophages in Breast Cancer

Conditional Myeloid-Specific Inhibition of UBE2N Hinders YUMM1.7 Growth

This study shows that inhibiting UBE2N in myeloid cells reduces YUMM1.7 melanoma growth by altering immune checkpoint molecules and SPP1 expression.

Highly plastic macrophage niches orchestrate acquired quiescence and reactivation in breast-cancer bone metastasis

The paper identifies CXCL16 macrophages in bone metastases that transiently restrain cancer growth and G-CSF niches that promote reactivation, revealing CAF-bone-marrow interactions as a therapeutic target.

A conditional, myeloid-cell specific estrogen receptor α deletion reprograms the liver immune microenvironment and impedes the growth of colon carcinoma liver metastases

This study shows that deleting estrogen receptor α in myeloid cells reduces liver metastases by altering the immune microenvironment and increasing cytotoxic T and NK cells.

Disrupting Myeloid Persistence and Replenishment Enables Sustained Control of Esophageal Squamous Cell Carcinoma

The paper shows that combining CSF1R inhibition with low-dose decitabine suppresses both myeloid persistence and replenishment, leading to sustained control of ESCC in multiple models.

CD24 Acts as an Evolutionarily Conserved Innate Immune Checkpoint in Colorectal Cancer

This study identifies CD24 as an innate immune checkpoint in colorectal cancer that promotes tumor survival by inhibiting macrophage-mediated clearance, validated through zebrafish models and human data.

Immune-enriched fibrovascular cores establish localized immunosuppressive niches in papillary malignancies

The paper identifies immune-enriched fibrovascular cores in papillary tumors that create immunosuppressive niches through PAI-1-driven macrophage fusion.

Hypoxia-conditioned HNSCC cell line secretomes drive phenotypic, functional, and transcriptional reprogramming of human neutrophils

This study shows hypoxia-conditioned HNSCC cell line secretomes reprogram human neutrophils to an immunomodulatory state with enhanced survival and stress pathways.

Tumor-derived stearic acid induces macrophage Egr2 signaling to suppress anti-tumor immunity in breast cancer

This study identifies stearic acid-induced Egr2 signaling in macrophages as a mechanism suppressing anti-tumor immunity in breast cancer, with oleic acid inhibiting this effect.

An IL-34-IGF-1 inflammatory axis fuels KRAS-mutant lung cancer progression

This study identifies an IL-34-IGF-1 axis between macrophages and KRAS-mutant lung tumor cells that promotes tumor progression and poor survival.