Systemic Sclerosis and Related Diseases

Development of a multi-organ single-cell atlas of systemic sclerosis reveals shared and tissue-specific pathogenic pathways.

This study creates a multi-organ single-cell atlas of systemic sclerosis to identify shared and tissue-specific transcriptional programs and potential therapeutic targets.

Spatial proteomic profiling of cardiac stromal populations and microenvironments in systemic sclerosis-associated primary myocardial involvement

The paper uses spatial proteomic profiling to analyze cardiac stromal populations and microenvironments in systemic sclerosis-associated myocarditis, identifying distinct fibroblast subtypes and their spatial interactions.

A mast cell receptor is associated with fibrosis and itch in systemic sclerosis

This study identifies Mrgprb2 as a mast cell receptor involved in fibrosis and itch in systemic sclerosis using a mouse model and human tissue analysis.