Raphael Micheroli

Development of a multi-organ single-cell atlas of systemic sclerosis reveals shared and tissue-specific pathogenic pathways.

This study creates a multi-organ single-cell atlas of systemic sclerosis to identify shared and tissue-specific transcriptional programs and potential therapeutic targets.

Synovitis in systemic sclerosis is an interferon-driven stromal condition distinct from rheumatoid arthritis

This study identifies SSc synovitis as an IFN-driven stromal condition distinct from RA, with implications for IFNAR1 blockade as a therapeutic strategy.

Human Fibroblast-Myeloid cell tissue atlas across lung, synovium, skin and heart

The paper analyzes scRNAseq data from multiple tissues to identify shared and tissue-specific myeloid and stromal cell populations in health and disease.

SNPic: SNP Topic Modeling for Interpretable Clustering of Complex phenotypes

SNPic uses topic modeling to cluster complex phenotypes by interpreting GWAS data as a corpus, identifying interpretable genetic modules and biological mechanisms.

Disease-specific fibroblast-myeloid interactions in rheumatoid arthritis synovium

This study identifies disease-specific fibroblast-myeloid interactions in RA synovium, showing SPP1 signaling and fibroblast-myeloid-dendritic interactions drive RA inflammation by linking innate immunity to autoimmunity.

Distinct myeloid precursors and their interaction with mesenchymal cells orchestrate the spreading of psoriatic disease from the skin to the joints

The paper identifies a unique myeloid precursor population that facilitates the spread of psoriatic inflammation from skin to joints, interacting with fibroblasts to regulate T cell IL-17 expression.

A reference single-cell map of freshly dissociated human synovium in inflammatory arthritis with an optimized dissociation protocol for prospective synovial biopsy collection

The paper optimizes a dissociation protocol for fresh synovial biopsies and creates a single-cell reference map of human synovium in inflammatory arthritis, revealing new cell types and functions.