Topic · Organic Chemistry · Chemistry
OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.
65 papers
Matthew E. H. White, Jesús Gil, Edward W. Tate
The paper analyzes cysteine accessibility in proteomic datasets to identify ligandable residues and proposes a framework for benchmarking cysteine profiling approaches.
bioRxiv · Dec 12, 2022 · PreprintBioinformatics
Keqing Nian, Yifang Liu, Yuchen Qiu, Zhuoyu Zhang, Laura Brigandi, Meni Wanunu, Sara H. Rouhanifard
The paper develops a DNA-enhanced CuAAC ligand for intracellular biomolecule labeling in live cells, demonstrating reduced copper toxicity and effective labeling.
bioRxiv · Nov 10, 2022 · PreprintMolecular Biology
Ji-Xiang He, Zhengcong Fei, Ling Fu, Caiping Tian, Fuchu He, Hao Chi, Jing Hui Yang
pChem assesses chemoproteomic probe performance by evaluating modification-homogeneity, profiling efficiency, and residue selectivity using isotopically coded probe-derived modifications.
Nature Chemical Biology · Jul 21, 2022Peer-reviewedBioinformatics
Aleksandra Arsić, Cathleen Hagemann, Nevena Stajković, Timm Schubert, Ivana Nikić
The paper establishes SPIEDAC labeling in living neurons for fluorescent protein labeling, enabling live-cell and super-resolution imaging with single-residue precision.
Nature Communications · Jan 14, 2022Peer-reviewedNeuroscience
Riley M. Bednar, Subhashis Jana, Sahiti Kuppa, Rachel Franklin, Joseph S. Beckman, Edwin Antony, Richard B. Cooley, Ryan A. Mehl
This paper introduces a method to site-specifically encode and label two noncanonical amino acids in proteins, enabling dual modification in living cells.
ACS Chemical Biology · Sep 30, 2021Peer-reviewedSynthetic Biology