Sahiti Kuppa

The paper compares Rad51 and Dmc1 recombinases using structural and functional analyses to show differences in their interfacial amino acids and evolutionary trajectories.

This study investigates RPA's long-distance migration on ssDNA using biophysical methods, finding that intersegmental transfer via multivalent interactions enables rapid diffusion under tension.

This study generates a fluorescently labeled human XPA protein to study DNA binding dynamics during nucleotide excision repair.

This paper describes fluorescently modified human RPA to study its dynamic interactions with ssDNA and other proteins.

This paper introduces a method to site-specifically encode and label two noncanonical amino acids in proteins, enabling dual modification in living cells.

This study characterizes human HELB as a monomeric helicase that binds ssDNA, hydrolyzes ATP, and clears RPA from ssDNA through translocation.