Cathleen Hagemann

Dynamic modelling of human neural crest development using a bioengineered stem cell organoid system

This paper introduces a bioengineered stem cell organoid system to model human neural crest development, showing it recapitulates key developmental dynamics and can be used for cross-species validation.

Brain-derived neurotrophic factor amplifies neuron-intrinsic programs to enhance axonal regeneration in human motor neurons

This study shows BDNF enhances axonal regeneration in human motor neurons by regulating RNA metabolism and cytoskeletal dynamics through kinase pathways.

Engineering Cortical Networks: An Open Platform for Controlled Human Circuit Formation and Synaptic Analysis In vitro

The paper introduces an open platform for creating functional cortical circuits using iPSC-derived neurons, enabling controlled network assembly and analysis of synaptic activity and connectivity.

VISIBLE: An imaging-driven system for sampling, biofabrication, and manipulation of complex biological models

VISIBLE is a system for real-time manipulation and bioprinting of complex in vitro models, enabling precise interventions and improving reproducibility in biomedical research.

Axonal length determines distinct homeostatic phenotypes in human iPSC derived motor neurons on a bioengineered platform

This study shows that axon length in human motor neurons affects their homeostatic mechanisms, revealing length-dependent molecular adaptations in cytoskeleton, translation, and mitochondria.

Minimal genetically encoded tags for fluorescent protein labeling in living neurons

The paper establishes SPIEDAC labeling in living neurons for fluorescent protein labeling, enabling live-cell and super-resolution imaging with single-residue precision.

Automated and unbiased classification of motor neuron phenotypes with single cell resolution in ALS tissue.

The paper develops an automated image processing pipeline with machine learning to classify motor neuron phenotypes in ALS tissue at single-cell resolution, revealing common morphological aberrations and validating their discriminative power between ALS and healthy tissue.

Formation of the substantia nigra requires Reelin-mediated fast, laterally-directed migration of dopaminergic neurons

This study identifies Reelin's role in promoting fast, laterally-directed migration of midbrain dopaminergic neurons through stabilization of leading processes and induction of bipolar morphology.