Blood properties and coagulation

Variability in Individual Native Fibrin Fiber Mechanics

This study examines how fibrinogen concentration affects the mechanical properties of individual fibrin fibers using atomic force microscopy and identifies two distinct behavior profiles.

Proteomic evidence for amyloidogenic cross-seeding in fibrinaloid microclots

The paper provides proteomic evidence that fibrinaloid microclots involve cross-seeding of non-fibrin proteins into amyloid structures, suggesting a complex mechanism beyond simple entrapment.

Whole genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles.

This study uses whole genome sequencing to identify 18 novel genetic loci associated with plasma fibrinogen levels, including variants more common in African populations and linked to liver-related traits and disease.

The chromatin-remodeling enzyme Smarca5 regulates erythrocyte aggregation via Keap1-Nrf2 signaling

This study shows that Smarca5 regulates erythrocyte aggregation through Keap1-Nrf2 signaling in zebrafish, leading to venous thrombosis-like phenotypes.

Association between erythrocyte dynamics and vessel remodelling in developmental vascular networks

The paper investigates how erythrocyte dynamics influence vascular remodelling in developing networks, finding that RBC depletion correlates with vessel regression and that plasma skimming drives this process.

A novel fibrinogen gamma-chain mutation, p. γAla327Val, causes structural abnormality of D region and ultimately leads to congenital dysfibrinogenemia

This study identifies a novel γAla327Val mutation in the FGG gene causing congenital dysfibrinogenemia by altering fibrinogen structure and function.

The plasma Factor XIII heterotetrameric complex structure: unexpected unequal pairing within a symmetric complex

The paper determines the structure of the FXIII-A2B2 complex, revealing asymmetric subunit pairing critical for its assembly and activation.

Lipopolysaccharide-binding protein (LBP) can reverse the amyloid state of fibrin seen or induced in Parkinson’s disease: implications for its aetiology

The paper shows that LBP prevents fibrin from adopting an amyloid form induced by LPS, suggesting a link between microbial products and Parkinson’s disease.