Topic · Pediatrics, Perinatology and Child Health · Medicine

Assisted Reproductive Technology and Twin Pregnancy

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

6 papers

Polygenic Scores for Dizygotic Twinning: Insights into the Genetic Architecture of Female Fertility

Nikki Hubers, Christian Magnus Page, René Pool, Hamdi Mbarek, Cornelis Bavo Lambalk, Velja Mijatovic, Lannie Ligthart, Jenny van Dongen, Siri E. Håberg, Elizabeth C. Corfield, Jeffrey J. Beck, Erik A. Ehli, Nicholas G. Martin, Gonneke A. H. M. Willemsen, Jennifer R. Harris, , Dorret Irene Boomsma

The paper develops a polygenic score for dizygotic twinning, showing it explains 1.6% of liability variance and is linked to fertility outcomes and genetic correlations with related conditions.

Journal of Assisted Reproduction and Genetics · May 26, 2025Peer-reviewedGenetic & Genomic Medicine

Examining Sex-Specific DNA Methylation and Variability Post In Vitro Fertilization

Melanie Lemaire, Wei Q. Deng, Keaton W Smith, Samantha L. Wilson

This study examines sex-specific DNA methylation and variability differences in placental tissue between IVF and spontaneous pregnancies, identifying significant shifts in variability and cell composition.

Molecular Human Reproduction · Jan 1, 2025Peer-reviewedGenomics

Genome-wide DNA methylation, imprinting, and gene expression in human placentas derived from Assisted Reproductive Technology

Pauliina Auvinen, Jussi Vehviläinen, K. Rämö, Ida Laukkanen, Heidi Marjonen, Essi Wallén, Viveca Söderström‐Anttila, Hanna K. Kahila, Christel Hydén‐Granskog, Timo Tuuri, Aila E. Tiitinen, Nina Kaminen‐Ahola

This study examines DNA methylation, imprinting, and gene expression in placentas from ART and control groups, identifying molecular changes linked to ART and subfertility.

Communications Medicine · Dec 19, 2024Peer-reviewedGenetic & Genomic Medicine

Transcriptomic and Metabolomic analyses in Monozygotic and Dizygotic twins.

Nikki Hubers, Gabin Drouard, Rick Jansen, René Pool, Jouke‐Jan Hottenga, Miina Ollikainen, Xiao-Ling Wang, Gonneke A. H. M. Willemsen, Jaakko A. Kaprio, Dorret Irene Boomsma, Jenny van Dongen

The paper compares transcriptomic and metabolomic data from monozygotic and dizygotic twins to identify molecular biomarkers of twinning, finding no replicable transcript-level differences but highlighting potential pathways.

American Journal of Medical Genetics Part A · Dec 16, 2024Peer-reviewedGenetic & Genomic Medicine

Whole-genome sequences reveal zygotic composition in chimeric twins

Sung-Soo Yoon, Chang Hyun Nam, Taewoo Kim, Jeong Seok Lee, Ryul Kim, Kijong Yi, June‐Young Koh, Jiye Kim, Hyein Won, Ji Won Oh, Obi L. Griffith, Malachi Griffith, Joohon Sung, Tae Yeul Kim, Duck Cho, , Young Seok Ju

The paper uses whole-genome sequencing to determine zygotic composition in chimeric twins, finding asymmetrical contributions from two zygotes in blood but not in buccal tissues.

Human Genetics and Genomics Advances · May 20, 2024Peer-reviewedGenomics

Babytwins Study Sweden (BATSS): A multi-method infant twin study of genetic and environmental factors influencing infant brain and behavioral development

Terje Falck‐Ytter, Linnea Hamrefors, Monica Siqueiros Sanchez, Ana Maria Portugal, Mark J. Taylor, Danyang Li, Charlotte Viktorsson, Irzam Hardiansyah, Lynnea Myers, Lars Westberg, Sven Bölte, Kristiina Tammimies, Angelica Ronald

The paper describes the Babytwins Study Sweden (BATSS), a longitudinal twin study combining EEG, eye tracking, genetics, and behavioral assessments to investigate genetic and environmental influences on infant brain and behavioral development.

Twin Research and Human Genetics · Aug 1, 2021Peer-reviewedNeuroscience