Gonneke A. H. M. Willemsen

This study analyzes T-cell receptor repertoires in monozygotic twins with and without Crohn's disease, finding increased TCR overlap in concordant pairs and identifying eight novel TCR clusters potentially linked to the disease.

The paper develops a polygenic score for dizygotic twinning, showing it explains 1.6% of liability variance and is linked to fertility outcomes and genetic correlations with related conditions.

The paper compares transcriptomic and metabolomic data from monozygotic and dizygotic twins to identify molecular biomarkers of twinning, finding no replicable transcript-level differences but highlighting potential pathways.

This study uses whole genome sequencing to identify 18 novel genetic loci associated with plasma fibrinogen levels, including variants more common in African populations and linked to liver-related traits and disease.

This study identifies genetic signals associated with age at menarche, highlights genes involved in pubertal development, and links reproductive timing to later life disease risk.

This study identifies genetic variants associated with income and shows they correlate with health outcomes and educational attainment.

This study identifies two CpGs associated with the gut microbiome genus Eggerthella and shows microbiome mediates environmental effects on DNA methylation.

The paper identifies smoking-reactive DNA methylation changes in monozygotic twins and shows reversibility upon smoking cessation.

This study identifies proteins and genes associated with BMI and its changes in twins, showing shared genetic and environmental factors across proteome, transcriptome, and metabolome layers.

The paper identifies genetic variants influencing DNA methylation in blood and shows their associations with complex traits and diseases, but finds limited direct causality.

The paper links genotype data from the Netherlands Twin Register to health care expenditure data and performs genome-wide association analyses, finding moderate heritability but no significant SNPs associated with expenditure.

The paper identifies 31 host genetic loci influencing gut microbiome composition through GWAS and suggests causal effects in inflammatory diseases.

This study estimates heritability and genetic contributions to metabolite levels using genome-wide data and twin-family cohorts, revealing class-specific genetic influences.

This study identifies 12 genetic loci associated with loneliness and finds genetic correlations with 34 health outcomes, including cardiovascular and psychiatric disorders.

This study identifies nine novel DNA methylation sites associated with fasting glucose and insulin levels by integrating cross-omics data from multiple cohorts.

This study identifies genetic effects on birth weight and their impact on cardio-metabolic traits, distinguishing fetal and maternal contributions.

This study identifies novel HPE genes and oligogenic inheritance patterns in holoprosencephaly by integrating clinical data with exome sequencing and gene prioritization.

This study identifies maternal genetic variants associated with offspring birth weight using GWAS and SEM, showing independent effects from fetal genetics.

The paper identifies 63 genetic signals associated with well-being traits using genome-wide analyses and links them to gene expression and methylation in brain tissues.