Barrier Structure and Function Studies

This study shows simvastatin preserves endothelial barrier function by modulating RhoB localization and activation through mevalonate-dependent mechanisms during TNF stimulation.

This study identifies oncostatin M-driven vascular leak in human endothelial cells through nanoscale channel formation, distinct from junction disassembly, and highlights potential therapeutic targets.

The paper shows that visual experience drives metabolic changes in endothelial cells by switching lactate and glucose transporters, essential for vascular and BBB maturation.

The paper identifies pericytes as vulnerable to oxidative stress and shows TRPA1 mediates their structural degeneration through ROS-1 activation.

This study investigates whether astrocyte-derived Wnt7a deficiency contributes to BMEC dysfunction during Plasmodium infection, finding no protective effect of Wnt7a overexpression on cerebral malaria outcomes.

The paper shows that female mice have higher cortical blood flow and reduced oxygen extraction fraction in middle age, with molecular and structural differences in white matter and microglial reactivity, without differences in systemic markers.

This study shows that breast cancer-derived PDGFB remodels the CNS vascular niche, promoting brain, spinal, and leptomeningeal metastasis through multiple mechanisms.

This study identifies CD36-associated vascular changes in Alzheimer's disease and shows CD36's role in regulating endothelial metabolic and immune programs, with potential for targeted therapies.

This study identifies cerebral microthrombi as focal sites of Cav-1-dependent BBB dysfunction after TBI, linking microvascular thrombosis to neuronal damage through transcytosis.

This study shows that Cyclin E/CDK2 deficiency enhances intestinal barrier integrity and tight junction expression in mice, contrary to initial hypotheses.

This study shows that NE52-QQ57 reduces post-ischemia protein phosphorylation and crosses the blood-brain barrier in mice.