Leptospirosis research and findings

Pathogenic Leptospira in dogs and rodents in Tha Wang Pha, Thailand - Prevalence, diversity and linked environments

This study identifies Leptospira species in dogs and rodents in Thailand, revealing new pathogen diversity and environmental associations.

Core-sheath coupling controls flagellar curvature and motility in Leptospira

This study reveals how core-sheath coupling in Leptospira flagella controls curvature and motility, showing its importance in viscous environments and infection.

Fatal Leptospirosis in Southern Sea Otters from Central California: Pathologic Findings and Detection of Leptospira interrogans

This study investigates leptospirosis in southern sea otters, finding that 74% tested positive for Leptospira interrogans serogroup Pomona, with 70% of positive cases linked to fatal outcomes.

Clinical and molecular characterization of an outbreak of leptospirosis in dogs from Los Angeles County, California, USA, 2021

This study characterizes a leptospirosis outbreak in dogs in Los Angeles County, finding that all isolates were Leptospira interrogans serovar Canicola, with urine PCR as the most sensitive test and ICFs as a potential source.

Genomic Analysis of Human-infecting Leptospira borgpetersenii isolates in Sri Lanka expanded PF07598 gene family repertoire, less overall genome reduction than bovine isolates

This paper reports the complete genomes of seven human-infecting Leptospira borgpetersenii isolates from Sri Lanka, showing less genome decay and expanded PF07598 gene family compared to bovine isolates.

First report of pathogenic Leptospira in Sri Lankan bats: A potential reservoir risk

This study identifies Leptospira in Sri Lankan bats, suggesting they may act as reservoirs for leptospirosis, with implications for public health.

Pathogenic Leptospira species identified in dogs and cats during neutering in Thailand

Molecular screening of bladder urine from 567 asymptomatic dogs and cats across seven Thai provinces detected pathogenic Leptospira in 9.8% of animals, including the first animal detection of Leptospira yasudae.

Complement C3 Deficiency Enhances Renal Leptospiral Load and Inflammation While Impairing T Cell Differentiation During Chronic Leptospira interrogans Infection

Leptospirosis in Campinas, Brazil: The interplay between drainage, impermeable areas, and social vulnerability

This study examines how drainage, impermeable areas, and social vulnerability influence leptospirosis risk in Campinas, Brazil, using spatial analysis of 83 cases.

Myocarditis and neutrophil-mediated vascular leakage but not cytokine storm associated with fatal murine leptospirosis

This study identifies myocarditis and neutrophil-mediated vascular leakage as key factors in fatal murine leptospirosis, distinct from cytokine storm or organ failure.

Time series models for prediction of Leptospirosis in different climate zones in Sri LankaTime series models for prediction of Leptospirosis in different climate zones in Sri Lanka

This study uses time series models to predict leptospirosis incidence in Sri Lanka based on meteorological data, finding varying associations between climate variables and disease rates across different zones.

Gene expression is associated with virulence in murine macrophages infected with Leptospira spp

The paper examines how virulent and attenuated Leptospira strains modulate host gene expression in murine macrophages, identifying virulence- and species-specific gene regulation.