Leptospirosis research and findings

Leptospira infection in European hedgehogs (Erinaceus europaeus): occurrence, diversity and associated risk factors in Greater Paris, France.

This study investigates Leptospira infection in hedgehogs in France, finding that 22% of tested individuals were positive, with L. interrogans SG5 and Australis serogroup as prevalent strains, and age and season as significant risk factors.

Pathogenic Leptospira in dogs and rodents in Tha Wang Pha, Thailand - Prevalence, diversity and linked environments

This study identifies Leptospira species in dogs and rodents in Thailand, revealing new pathogen diversity and environmental associations.

β-Lactam antibiotics trigger mouse TLR2/4- and human TLR2/5-dependent Jarisch-Herxheimer reaction in leptospirosis

This study shows beta-lactam antibiotics induce a Jarisch-Herxheimer reaction in leptospirosis through TLR2/4 and TLR2/5-dependent mechanisms in mice and humans.

Core-sheath coupling controls flagellar curvature and motility in Leptospira

This study reveals how core-sheath coupling in Leptospira flagella controls curvature and motility, showing its importance in viscous environments and infection.

Host-like Temperature Unlocks Glucose Uptake and Metabolism in Pathogenic Leptospira

This study shows that pathogenic Leptospira uses glucose under host-like temperatures, contradicting previous assumptions about its metabolic capabilities.

Fatal Leptospirosis in Southern Sea Otters from Central California: Pathologic Findings and Detection of Leptospira interrogans

This study investigates leptospirosis in southern sea otters, finding that 74% tested positive for Leptospira interrogans serogroup Pomona, with 70% of positive cases linked to fatal outcomes.

Clinical and molecular characterization of an outbreak of leptospirosis in dogs from Los Angeles County, California, USA, 2021

This study characterizes a leptospirosis outbreak in dogs in Los Angeles County, finding that all isolates were Leptospira interrogans serovar Canicola, with urine PCR as the most sensitive test and ICFs as a potential source.

Soil bacterium Massilia secretes metabolites that promote Leptospira growth

This study identifies metabolites from the soil bacterium Massilia that promote Leptospira growth, revealing a metabolic interaction between environmental bacteria and a pathogen.

A Machine Learning Framework for Serogroup Classification of pathogenic species of Leptospira Based on rfb Locus Profiles

This paper develops a machine learning framework to classify Leptospira serogroups using genomic data, achieving high accuracy and offering a scalable alternative to traditional serological methods.

Genomic Analysis of Human-infecting Leptospira borgpetersenii isolates in Sri Lanka expanded PF07598 gene family repertoire, less overall genome reduction than bovine isolates

This paper reports the complete genomes of seven human-infecting Leptospira borgpetersenii isolates from Sri Lanka, showing less genome decay and expanded PF07598 gene family compared to bovine isolates.

Metabolites from plasma-like medium fuel nitrogen metabolism and influence proliferation in Leptospira interrogans

This study identifies glutamine as a key nitrogen source for Leptospira interrogans under physiological conditions and shows that targeting glutamine metabolism could inhibit bacterial proliferation and infection.

First report of pathogenic Leptospira in Sri Lankan bats: A potential reservoir risk

This study identifies Leptospira in Sri Lankan bats, suggesting they may act as reservoirs for leptospirosis, with implications for public health.

A novel periplasmic layer formed by an outer membrane lipo-protein governs the cell-envelope integrity and stiffness of Leptospira interrogans

This study identifies LipL32 as a key structural protein in Leptospira interrogans that maintains cell-envelope integrity and stiffness, affecting pathogenicity.

Pathogenic Leptospira species identified in dogs and cats during neutering in Thailand

Molecular screening of bladder urine from 567 asymptomatic dogs and cats across seven Thai provinces detected pathogenic Leptospira in 9.8% of animals, including the first animal detection of Leptospira yasudae.

Integrative Transcriptomic and Network Analysis Reveals Small Open Reading Frames as Regulators of DNA Methylation-Linked Pathogenicity and Adaptability in Leptospira interrogans

The paper identifies sORFs in Leptospira interrogans that link DNA methylation to pathogenicity and adaptability through transcriptomic and network analysis.

Complement C3 Deficiency Enhances Renal Leptospiral Load and Inflammation While Impairing T Cell Differentiation During Chronic Leptospira interrogans Infection

Leptospirosis in Campinas, Brazil: The interplay between drainage, impermeable areas, and social vulnerability

This study examines how drainage, impermeable areas, and social vulnerability influence leptospirosis risk in Campinas, Brazil, using spatial analysis of 83 cases.

Biochemical characterization of the sole Leptospira interrogans diadenylate cyclase

This study characterizes the diadenylate cyclase CdaA in Leptospira interrogans, showing it produces c-di-AMP and its activity depends on specific divalent cations.

In Vivo Dual RNA-Seq uncovers key toxin-like effectors of epithelial barrier disruption and tissue colonization by an extracellular bacterial pathogen

This study uses dual RNA-Seq to identify bacterial effectors that disrupt host cell junctions and enable Leptospira colonization by modulating calcium signaling.

TLR4 competence and mouse models of leptospirosis

This study compares TLR4-competent and hyporesponsive mouse strains to determine their susceptibility to leptospirosis, finding that TLR4 function is important but not sufficient for disease susceptibility.

Myocarditis and neutrophil-mediated vascular leakage but not cytokine storm associated with fatal murine leptospirosis

This study identifies myocarditis and neutrophil-mediated vascular leakage as key factors in fatal murine leptospirosis, distinct from cytokine storm or organ failure.

DMEM and EMEM are suitable surrogate media to mimic host environment and expand leptospiral pathogenesis studies using in vitro tools

This paper identifies DMEM and EMEM as better in vitro media for studying leptospiral pathogenesis compared to EMJH and HAN by mimicking host gene expression profiles.

Description of the structural and functional genomic composition of L. santarosai serovar Alice

The paper describes the structural and functional genomic composition of L. santarosai serovar Alice, identifying genomic features and comparing them to other Leptospira species.

Comparative genomic analysis of a Colombian strain of Leptospira santarosai serogroup Autumnalis serovar Alice and inference of its virulence factors

The paper sequences and analyzes the genome of a Colombian Leptospira santarosai strain to identify virulence factors and core-genome characteristics.

Host population structure and rare dispersal events drive leptospirosis transmission patterns among Rattus norvegicus in Boston, Massachusetts, US

The paper investigates leptospirosis transmission among brown rats in Boston, finding high genetic structure and limited dispersal, with Leptospira clades linked to specific rat populations and a human case linked to rats.

Genetic structure and diversity of rfb locus of pathogenic species of genus Leptospira

The paper identifies genetic patterns in the rfb locus of Leptospira species to propose molecular markers for serogroup classification.

Time series models for prediction of Leptospirosis in different climate zones in Sri LankaTime series models for prediction of Leptospirosis in different climate zones in Sri Lanka

This study uses time series models to predict leptospirosis incidence in Sri Lanka based on meteorological data, finding varying associations between climate variables and disease rates across different zones.

Comparative analysis of whole genome sequences of Leptospira spp. from RefSeq database provide interspecific divergence and repertoire of virulence factors

The paper uses comparative genomics to analyze whole genome sequences of Leptospira spp., identifying virulence factors and reclassifying species based on genetic divergence.

Gene expression is associated with virulence in murine macrophages infected with Leptospira spp

The paper examines how virulent and attenuated Leptospira strains modulate host gene expression in murine macrophages, identifying virulence- and species-specific gene regulation.

A potential genomic recombination site upstream of the rfb locus in Leptospira interrogans is associated with serogroup Serjoe and serovar Hardjo classification