Vascular Tumors and Angiosarcomas

MYC drives endothelial transformation and dedifferentiation in angiosarcoma

This study shows MYC drives endothelial transformation and dedifferentiation in angiosarcoma by promoting lineage plasticity and cell growth.

Subclonal IDH1/2 Mutations as a Targetable Vulnerability in Vascular Tumors

This study identifies low-variant allele frequency IDH1/2 mutations in sporadic angiosarcoma and shows they drive tumorigenesis through non-cell-autonomous mechanisms, responding to ivosidenib treatment.

EHE cell cultures: a platform for mechanistic and therapeutic investigation

The paper develops EHE primary cell cultures to study the disease's mechanisms and test therapies, finding they exhibit EHE features and respond to TEAD inhibitors.

IL-13/IL-13Rα2 axis promotes proliferation of angiosarcoma cells

The paper identifies the IL-13/IL-13R2 axis as a driver of angiosarcoma cell proliferation and suggests it as a potential therapeutic target.

A novel SERPINE1-FOSB fusion gene in a case of pseudomyogenic hemangioendothelioma results in activation of intact FOSB and the PI3K-AKT-mTOR signaling pathway and responsiveness to sirolimus

This study reports a novel SERPINE1-FOSB fusion gene in pseudomyogenic hemangioendothelioma that activates the PI3K-AKT-mTOR pathway and responds to sirolimus treatment.