Discovery of baicalin and baicalein as novel, natural product inhibitors of SARS-CoV-2 3CL protease in vitro
Haixia Su, Sheng Yao, Wenfeng Zhao, Minjun Li, Jia Liu, Weijuan Shang, Hang Xie, Chang‐Qiang Ke, Mei-na Gao, Kunqian Yu, Hong Shu Liu, Jingshan Shen, Wei Tang, Leike Zhang, Jianping Zuo, , Yechun Xu
Baicalin and baicalein from Scutellaria baicalensis inhibit SARS-CoV-2 3CL protease non-covalently; a 2.2 Å baicalein complex structure shows an unusual shield-like binding mode.
bioRxiv · Apr 13, 2020 · PreprintMolecular Biology✦ In-depth digest