Flavonoids in Medical Research

Combined effect of baicalein and thermal-cycling stimulation on suppressing non-small cell lung cancer A549 cells under CoCl2-induced hypoxia

This study shows that combining baicalein and thermal-cycling stimulation reduces viability and induces apoptosis in NSCLC cells under hypoxia with minimal toxicity to normal cells.

Molecular and spatial characterization of baicalin from Scutellaria baicalensis hairy root culture

This study verifies the molecular structure of baicalin isolated from Scutellaria baicalensis hairy root culture using X-ray diffraction and NMR spectroscopy, confirming its high purity and structural consistency.

Alkoxylated fisetin derivatives - the new potential drugs against head and neck cancers

This study identifies alkoxylated fisetin derivatives as potential non-genotoxic agents that induce apoptosis in head and neck squamous cell carcinoma cells with low toxicity to normal cells.

Integrated multi-omics analysis of Klebsiella pneumoniae revealed the discrepancy in flavonoid effect against strain growth between Rutin and Luteolin

The paper compares the effects of Rutin and Luteolin on Klebsiella pneumoniae using metabolomic and transcriptomic analysis to identify differences in their inhibitory mechanisms.

Discovery of baicalin and baicalein as novel, natural product inhibitors of SARS-CoV-2 3CL protease in vitro

Baicalin and baicalein from Scutellaria baicalensis inhibit SARS-CoV-2 3CL protease non-covalently; a 2.2 Å baicalein complex structure shows an unusual shield-like binding mode.