Author

Leike Zhang

Chinese Academy of SciencesORCID 0000-0002-2593-2571Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:protein structure· 1 Organism:virus· 1

Frequent Co-Authors

Hualiang JiangiD· 2 shared Chang‐Qiang Ke· 1 shared Erli You· 1 shared Fang BaiiD· 1 shared Fulai ZhouiD· 1 shared Gengfu XiaoiD· 1 shared H. Eric XuiD· 1 shared Haixia SuiD· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMolecular Biology

Hualiang JiangORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintOct 6, 2020

Structural basis for repurposing a 100-years-old drug suramin for treating COVID-19

Wanchao Yin, Xiaodong Luan, Zhihai Li…·H. Eric Xu

The paper discovers suramin as a potent inhibitor of SARS-CoV-2 RNA polymerase and provides its structural mechanism for repurposing in treating COVID-19.

5 citations

experimental assaydrug response / drug discovery

Molecular BiologybioRxivPreprintApr 13, 2020

✦ In-depth digest

Discovery of baicalin and baicalein as novel, natural product inhibitors of SARS-CoV-2 3CL protease in vitro

Haixia Su, Sheng Yao, Wenfeng Zhao…·Yechun Xu

Baicalin and baicalein from Scutellaria baicalensis inhibit SARS-CoV-2 3CL protease non-covalently; a 2.2 Å baicalein complex structure shows an unusual shield-like binding mode.

143 citations

virusprotein structure