Cancer, Stress, Anesthesia, and Immune Response

TrkA+ sensory neurons regulate osteosarcoma proliferation and vascularization to promote disease progression

This study shows that TrkA+ sensory neurons promote osteosarcoma progression by enhancing tumor growth, vascularization, and metastasis, and that inhibiting these neurons reduces disease severity and improves survival.

TUMOR-INFILTRATING NOCICEPTOR NEURONS PROMOTE IMMUNOSUPPRESSION

This study shows that nociceptor neurons promote immunosuppression in tumors by increasing MDSC infiltration and CD8+ T cell exhaustion through IL-6 and sEVs.

Molecular and cellular features of nerve-invaded cancer cells using a newly characterized experimental model

This study establishes a DRG-nerve explant model for perineural invasion (PNI) and identifies molecular and cellular features of PNI in cancer cells.

Characterizing postoperative T and B cell dysfunction in cancer surgery patients, using COVID-19 as a model antigen

This study examines how cancer surgery affects T and B cell responses to a model antigen, showing reduced cytokine-producing CD8+ T cells and antibody-secreting B cells post-surgery.

Pancreatic Schwann cell reprogramming supports cancer-associated neuronal remodeling

This study shows pancreatic Schwann cells reprogram during cancer development, promoting sympathetic nerve sprouting and a protective antitumor response.