Cancer, Stress, Anesthesia, and Immune Response

A polysynaptic hypothalamuspelvic-ganglion circuit regulates prostate tumor growth via WNT3A

The paper identifies a polysynaptic hypothalamus-pelvic-ganglion circuit that promotes prostate tumor growth through WNT3A signaling in mice.

Stromal control of sympathetic rewiring in metastatic lymph nodes

This study shows that tumor-driven remodeling of metastatic lymph nodes involves sympathetic neural rewiring mediated by stromal HGF and mechanical cues.

Differential Impact of Isoflurane and Propofol on Apoptotic Regulation of Helper T cells

This study compares the effects of isoflurane and propofol on apoptosis in CD4+ T cells, showing isoflurane induces apoptosis via ROS-p38-caspase-3/7 pathway, while propofol protects mitochondrial function.

The mutational landscape of innervation axes in cancer

This study analyzes mutations in neural signaling pathways across cancers, finding 65% of patients have alterations linked to poor survival and complex pathway interactions.

Correlation analysis of changes in the expression of C1qtnf superfamily genes in the hypothalamus, thymus, and lungs against the background of chronic social stress during the development of Lewis lung adenocarcinoma in mice

This study examines how chronic social stress and Lewis lung adenocarcinoma affect C1qtnf gene expression in the hypothalamus, thymus, and lungs of mice, finding significant correlations and tissue-specific changes.

A brain-tumour axis links chronic stress to gastric cancer progression through NPY signalling

The paper identifies a brain-tumour axis linking chronic stress to gastric cancer progression via NPY signalling, showing NPY1R as a therapeutic target.

Tyrosine hydroxylase–mediated neuroimmune crosstalk regulates antitumor immunity in glioblastoma during oncolytic herpes virotherapy

This study shows that tyrosine hydroxylase-mediated neuroimmune signaling in glioblastoma affects antitumor immunity and enhances oncolytic virotherapy efficacy.

Sensory neurons inhibit invadopodia and metastasis via direct CGRP-RAMP1-cAMP signaling to cancer cells

This study shows sensory neurons inhibit breast cancer metastasis via CGRP-RAMP1-cAMP signaling, which suppresses invadopodia and ECM degradation.

Adrenergic signaling induces a pro-tumorigenic B cell state in colorectal cancer

This study shows adrenergic signaling promotes a pro-tumorigenic B cell state in colorectal cancer by altering their transcriptome and function, linking neuronal activity to immune responses and patient survival.

Neuronal innervation of breast cancer promotes metastatic dissemination

This study investigates the role of neuronal innervation in breast cancer metastasis using a MMTV-PyMT model and denervation with RTX, finding that denervation reduces metastasis without affecting tumor growth.

Cancer-induced Nerve Injury Unveils a Sympathetic-to-Sensory Nerve Axis in Head and Neck Cancer

The paper identifies reciprocal plasticity and crosstalk between sympathetic and sensory nerves in oral squamous cell carcinoma, linking them to tumor progression and neuropathic-like pain.

A novel mouse model of voluntary stretching and its application in breast cancer research

This paper develops a voluntary stretching model in mice and applies it to study its effects on breast tumor growth and plasma protein profiles compared to running.

Weekly inhaled salmeterol xinafoate, a selective β2 adrenergic receptor agonist drug, therapeutically inhibits cancer growth and prolongs survival in vivo

This study shows that weekly inhaled salmeterol xinafoate inhibits cancer growth and prolongs survival in vivo by targeting the β2AR receptor on cancer cells.

CCR2 silencing in sensory neurons blocks bone cancer progression

This study shows that silencing CCR2 in sensory neurons blocks bone cancer progression and alleviates pain by disrupting neuropeptide-driven tumor growth.

Sympathetic Signals Promote Immunosuppressive Neutrophils in Lung Tumors

This study identifies sympathetic signals promoting immunosuppressive neutrophils in lung tumors and shows that blocking these signals enhances immunotherapy.