Pharmacological Effects of Natural Compounds

Elucidation of the anti-inflammatory mechanism of isoliquiritigenin from Glycyrrhiza uralensis using activity-based protein profiling

This study identifies L-PGDS as a covalent target of isoliquiritigenin, revealing its anti-inflammatory mechanism through suppression of PGD2 production.

Stable isotope-assisted computational mass spectrometry reveals root-specific alkaloids in Glycyrrhiza species

The paper uses stable isotope-assisted mass spectrometry to identify root-specific alkaloids in Glycyrrhiza species and proposes their biosynthetic pathway.

Diammonium glycyrrhizinate injection promotes zebrafish angiogenesis through the mTOR/HIF-1 signaling pathway

This study investigates the pro-angiogenic effects of GA preparations in zebrafish, finding that diammonium glycyrrhizinate injection (DGI) activates the mTOR/HIF-1 signaling pathway to promote angiogenesis.

Potential Pharmacodynamic Mechanism of the Main ingredients in Licorice for Chronic Obstructive Pulmonary Disease

This study identifies potential pharmacodynamic mechanisms of licorice ingredients in treating COPD using network pharmacology.

An artificial intelligence system reveals liquiritin inhibits SARS-CoV-2 by mimicking type I interferon

The paper identifies liquiritin as an antiviral compound that inhibits SARS-CoV-2 by mimicking type I interferon, showing efficacy in cell cultures and low toxicity in mice.