Topic · Pharmacology · Pharmacology, Toxicology and Pharmaceutics
OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.
7 papers
Hina Sakai, Mi Hwa Chung, Taiki Nakaya, Katsuya Ohbuchi, Yosuke Isobe, Makoto Arita, Kazuya Tsumagari, Koshi Imami, Takatsugu Hirokawa, Hiroshi Tsugawa
This study identifies L-PGDS as a covalent target of isoliquiritigenin, revealing its anti-inflammatory mechanism through suppression of PGD2 production.
bioRxiv · May 8, 2026 · PreprintBiochemistry
Keita Sawai, Yoshimasa Todoroki, Shohei Nakamukai, Yuki Matsuzawa, Keiichi Noguchi, Toshiyo Kato, Tetsuya Mori, Amit Rai, Masami Yokota Hirai, Hiroshi Tsugawa
The paper uses stable isotope-assisted mass spectrometry to identify root-specific alkaloids in Glycyrrhiza species and proposes their biosynthetic pathway.
bioRxiv · May 8, 2026 · PreprintBiochemistry
Saki Kiuchi, Mi Hwa Chung, Hina Sakai, Taiki Nakaya, Katsuya Ohbuchi, Kazuya Tsumagari, Koshi Imami, Yasuhiro Otoguro, Tomoaki Nitta, Hiroyuki Yamamoto, Kazunori Sasaki, Hiroshi Tsugawa
This study uses multiomics to analyze the anti-inflammatory effects of Glycyrrhiza uralensis and isoliquiritigenin in macrophages, identifying metabolic and phosphorylation changes associated with inflammation suppression.
npj Systems Biology and Applications · Dec 13, 2025Peer-reviewedSystems Biology
Shuqing Yu, Jiahao Yu, Fengzhi Sun, Xuanming Zhang, Wenlong Sheng, Kechun Liu, Xiaobin Li, Wei Li
This study investigates the pro-angiogenic effects of GA preparations in zebrafish, finding that diammonium glycyrrhizinate injection (DGI) activates the mTOR/HIF-1 signaling pathway to promote angiogenesis.
bioRxiv · Feb 19, 2025 · PreprintPharmacology & Toxicology
Cai Chen, Jianpeng An, Guodong Shen, Yang Shen
This study identifies potential pharmacodynamic mechanisms of licorice ingredients in treating COPD using network pharmacology.
bioRxiv · Aug 29, 2021 · PreprintBioinformatics
Lukas van de Sand, Maren Bormann, Mira Alt, Leonie Schipper, Christiane Silke Heilingloh, Eike Steinmann, Daniel Tödt, Ulf Dittmer, Carina Elsner, Oliver Witzke, Adalbert Krawczyk
This study shows glycyrrhizin inhibits SARS-CoV-2 main protease and neutralizes the virus in vitro, suggesting it as a potential antiviral treatment for COVID-19.
Viruses · Apr 2, 2021Peer-reviewedMolecular Biology
Jie Zhu, Yong‐Qiang Deng, Xin Wang, Xiao-Feng Li, Nana Zhang, Zurui Liu, Bowen Zhang, Cheng‐Feng Qin, Zhengwei Xie
The paper identifies liquiritin as an antiviral compound that inhibits SARS-CoV-2 by mimicking type I interferon, showing efficacy in cell cultures and low toxicity in mice.
bioRxiv · May 2, 2020 · PreprintSystems Biology