Renal function and acid-base balance

Illuminating the renal response to pH stress with single-nucleus RNA sequencing

This study uses single-nucleus RNA sequencing to investigate sex-specific transcriptional responses of the kidney to acidosis and alkalosis in mice.

Renal proximal tubules are sensitive to metabolic acidosis

This paper shows that proximal tubules are sensitive to metabolic acidosis, leading to trafficking defects and lysosomal damage, and that bicarbonate therapy can prevent these issues.

Introduction of single nucleotide variations into the promoter region of the mouse kidney anion exchanger 1 gene downstream of a TATA box changes its transcriptional activity.

The paper introduces single nucleotide variations into the murine kAE1 promoter downstream of a TATA box and assesses their effect on promoter activity, finding reduced activity for some variants.