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Topic · Immunology · Immunology and Microbiology

Macrophage Migration Inhibitory Factor

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

5 papers

Mapping the MIF-2 Chemokine Interactome Reveals MIF-2-CCL20 Complex Formation in Liver Fibrosis

Adrian Hoffmann, Markus Brandhofer, Yufei He, Genta Bushati, Elena Siminkovitch, Xavier Blanchet, Michael K. Otabil, Lin Zhang, Simon Ebert, Mathias Holzner, Christine Krammer, Kathleen Hille, Christian Werner Wichmann, Hanno Nieß, Omar El Bounkari, , Jürgen Bernhagen

The paper identifies MIF-2-CCL20 complex formation in liver fibrosis through biochemical and computational methods, showing its role in modulating immune and stromal responses.

bioRxiv · Mar 3, 2026 · PreprintImmunology

MIF-induced CD74+ microglia/macrophages are clinically relevant disease-associated subpopulations in brain metastasis and other CNS disorders

Laura Álvaro‐Espinosa, Ángel Márquez-Galera, Neibla Priego, Virginia García-Calvo, María Perea-García, Carolina Hernández-Oliver, Diana Retana, Oliva Sánchez, Ana de Pablos-Aragoneses, Pedro García‐Gómez, Osvaldo Graña‐Castro, Óscar Lapuente-Santana, Fátima Al‐Shahrour, Ana Cayuela, Isabel Peset, , Manuel Valiente

The paper identifies CD74+ microglia/macrophages driven by MIF as clinically relevant subpopulations in brain metastasis and other CNS disorders, showing their role in disease progression and therapeutic targeting potential.

bioRxiv · Sep 6, 2025 · PreprintCancer Biology

Allosteric Modulation of MIF-2 Structure, Catalysis, and Biological Signaling via Cysteine Residues and a Small Molecule, Ebselen

Vinnie Widjaja, Sirena M. D’Orazio, Pragnya Das, Xander Takada, Divya Rajendran, Yuanjun Shi, Iz Varghese, Yannie Lam, Jimin Wang, Víctor S. Batista, Vineet Bhandari, George P. Lisi

This study investigates how Ebselen modulates MIF-2 structure, catalysis, and signaling through cysteine residues, revealing its impact on trimer stability and function.

bioRxiv · May 15, 2025 · PreprintBiophysics

Hepatic Macrophage Migration Inhibitory Factor Promotes Pancreatic Cancer Liver Metastasis in NAFLD

Qian Yu, Hui Song, Liang Zhu, Xiao-ya Shi, Haizhen Wang, Ying-luo Wang, Ruining Gong, Jiu-fa Cui, Xiaonan Yang, Jigang Wang, Yu Liang, Ying Chen, Xiaowu Dong, Guotao Lu, Chang Li, , He Ren

This study shows that hepatic MIF promotes PDAC liver metastasis in NAFLD by enhancing cancer stemness and immune suppression through the MIF-CD44 axis.

bioRxiv · Jun 2, 2024 · PreprintCancer Biology

Macrophage Migration Inhibitory Factor · papers · henhao