MIF-induced CD74+ microglia/macrophages are clinically relevant disease-associated subpopulations in brain metastasis and other CNS disorders
Laura Álvaro‐Espinosa, Ángel Márquez-Galera, Neibla Priego, Virginia García-Calvo, María Perea-García, Carolina Hernández-Oliver, Diana Retana, Oliva Sánchez, Ana de Pablos-Aragoneses, Pedro García‐Gómez, Osvaldo Graña‐Castro, Óscar Lapuente-Santana, Fátima Al‐Shahrour, Ana Cayuela, Isabel Peset, , Manuel Valiente
The paper identifies CD74+ microglia/macrophages driven by MIF as clinically relevant subpopulations in brain metastasis and other CNS disorders, showing their role in disease progression and therapeutic targeting potential.
bioRxiv · Sep 6, 2025 · PreprintCancer Biology