Biochemical effects in animals

Salicyl-Carnosine Protects Primary Cortical Rat Neuron Cultures in Conditions of Oxygen-Glucose Deprivation and NMDA-Induced Excitotoxicity by Preventing Oxidative Stress

This study shows that salicyl-carnosine protects rat cortical neurons from oxygen-glucose deprivation and NMDA-induced excitotoxicity by reducing oxidative stress and modulating apoptotic and kinase pathways.

Carnosinylation of Cardiac Antigens Attenuates Immunogenic Responses and Improves Function in Failing Hearts

This study shows that increasing carnosine levels in failing hearts reduces aldehyde stress and immune activation, preserving cardiac function.

N-acetylcarnosine attenuates age-associated declines in multi-organ systems to improve survival

This study shows that N-acetylcarnosine treatment improves survival and delays age-related decline in multiple organ systems in female mice.

The carnosinase dipeptidase CNDP1 is a novel metabolic vulnerability in brain metastasis

This study identifies CNDP1 as a metabolic vulnerability in brain metastasis, showing its inhibition suppresses metastasis and its expression confers metastatic potential.

Multiomics reveals the genomic, proteomic and metabolic influences of histidyl dipeptides on heart

This study uses multiomics to show histidyl dipeptides regulate heart function by altering microRNAs, proteins, and metabolites involved in fatty acid oxidation and the TCA cycle.

GADL1 is a multifunctional decarboxylase with tissue specific roles in β-alanine and carnosine production

This study identifies GADL1 as a multifunctional enzyme involved in β-alanine and carnosine production, showing its tissue-specific roles and associations with physiological traits in mice and humans.