Jeffrey Colm Glennon

Genome-Wide Association Analysis of Tic Disorders Reveals 6 Independent Risk Loci and Highlights Tic-Associated Cell Types and Brain Circuitry

This study identifies six genome-wide significant risk loci for tic disorders and links genetic risk to specific brain cell types and circuits.

Brain Age in Conduct Disorder: A Mega-Analysis of the ENIGMA Antisocial Behavior Working Group

This study investigates brain age differences in youth with conduct disorder compared to controls, finding accelerated brain maturation in those with adolescence-onset CD.

KCNQ1 regulates human neuronal development through mitochondrial and insulin signalling pathways

This study shows KCNQ1 regulates human neuronal development by affecting cell adhesion, mitochondrial function, and insulin signalling pathways.

Genome-wide Association Study identifies two novel loci for Gilles de la Tourette Syndrome

This study identifies two novel genetic loci associated with Tourette Syndrome through a genome-wide meta-analysis and integrates functional data to implicate specific genes.

Uncovering the Genetic Architecture of Broad Antisocial Behavior through a Genome-Wide Association Study Meta-analysis.

This study identifies genetic variants associated with antisocial behavior through a genome-wide association meta-analysis, finding significant links to FOXP2 and correlations with multiple health and behavioral traits.

Anterior cingulate cortex hypofunction causes anti-social aggression in mice

This study shows that ACC hypofunction in mice leads to anti-social aggression, with chemogenetic activation of ACC reducing this behavior.

GADL1 is a multifunctional decarboxylase with tissue specific roles in β-alanine and carnosine production

This study identifies GADL1 as a multifunctional enzyme involved in β-alanine and carnosine production, showing its tissue-specific roles and associations with physiological traits in mice and humans.

Reactive/proactive aggression specific cortical and subcortical alterations in children and adolescents with disruptive behavior

The paper examines structural brain differences in children and adolescents with aggressive behavior, finding subtype-specific volume reductions in regions linked to decision making and empathy.

A hundred genes implicated in intellectual disability and autism regulate habituation learning and reveal an opposing role for Ras-MAPK signaling in inhibitory and excitatory neurons

The paper identifies over 100 genes linked to intellectual disability and autism that regulate habituation learning, revealing opposing roles for Ras-MAPK signaling in inhibitory and excitatory neurons.

Aggression Subtypes Relate to Distinct Resting State Functional Connectivity in Disruptive Children and Adolescents

The paper examines how reactive and proactive aggression subtypes relate to distinct resting state functional connectivity patterns in children and adolescents with disruptive behavior.

Different Whole-Brain Functional Connectivity Correlates of Reactive-Proactive Aggression and Callous-Unemotional Traits in Disruptive Children and Adolescents

The paper examines functional connectivity differences in children and adolescents with disruptive behavior, finding distinct patterns for reactive and proactive aggression and callous-unemotional traits, emphasizing the role of comorbid symptoms.