Jan Haavik

This study identifies 118 new genetic loci associated with Alzheimer's disease across diverse ancestries and discovers 48 novel risk loci, including those enriched in neuronal cell types.

This study identifies distinct genetic overlaps between Alzheimer's and Parkinson's disease and metabolic markers, revealing disease-specific pathways involving lipid metabolism and synaptic processes.

The paper identifies novel CNV loci and dose-dependent gene effects across six psychiatric disorders using genome-wide analysis.

This study conducts a large-scale GWAS of OCD, identifying 15 new genome-wide significant loci and linking OCD to multiple cortical regions and cell types.

The paper investigates how phenylalanine and tyrosine levels affect dopamine production in PC12 cells, revealing molecular mechanisms linking these amino acids to dopamine synthesis in PKU and TYRSN1.

The paper demonstrates a data harmonization process for memory testing across 53 studies, reducing inter-site variance while preserving covariate effects.

The paper investigates genetic overlaps between neuropsychiatric disorders and insulin-related diseases, finding significant genetic correlations and suggesting potential clusters of disorders with divergent pleiotropic effects.

This study conducts a genome-wide association meta-analysis of childhood aggression across multiple raters, instruments, and ages, identifying genetic correlations with various traits but no genome-wide significant SNPs.

This study analyzes structural brain asymmetries in ADHD using 39 datasets, finding small effects that do not meet study-wide significance thresholds.

This study uses machine learning to show that structural brain anomalies in ADHD are similar in children and adults, supporting continuity of the disorder's pathophysiology.

This study identifies GADL1 as a multifunctional enzyme involved in β-alanine and carnosine production, showing its tissue-specific roles and associations with physiological traits in mice and humans.

This study identifies nine new genetic loci associated with ADHD and shows shared genetic architecture between childhood and adult ADHD.

The paper investigates how genetic variation in DRD4 interacts with seasonal daylight changes to influence inattention, finding support for the Spring-focus hypothesis and seasonal patterns in ADHD-related symptoms.

This study performs a cross-disorder GWAS meta-analysis of ADHD, ASD, OCD, and TS, identifying 297 genome-wide significant variants and 21 genes associated with shared genetic risk.

This study compares structural brain differences across ADHD, ASD, and OCD using MRI data from multiple cohorts, finding disorder-specific alterations in brain volume and cortical thickness.

Genome-wide association meta-analysis of 20,183 ADHD cases and 35,191 controls finds 12 significant loci; signal concentrates in conserved regions, constrained genes, and CNS regulatory elements.

This study investigates genetic mechanisms underlying sex bias in ADHD prevalence using genome-wide data and finds no mean polygenic burden difference across sexes but increased risk in female siblings and comorbid conditions.