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This paper develops a multichannel microendoscope for in-organ cellular imaging, achieving subcellular resolution and enabling functional studies in various tissues.

The paper maps antibody binding epitopes on human arginase-1 using amber codon mutational scanning and bioorthogonal PEGylation, revealing SAC incorporation efficiency and residue reactivity.

This study introduces a transparent, flexible electrode for brain stimulation compatible with optical imaging, demonstrating its ability to generate up to 300 V/m electric field in a mouse brain.

This study develops injectable hydrogel-drug complexes that synchronize chemoimmunotherapy release to treat brain tumors in mice, achieving long-term survival and protection from rechallenge.

This paper develops a mechanically resilient hydrogel for drug delivery in physically active joints, showing sustained release and reduced cartilage degeneration in a mouse model of post-traumatic osteoarthritis.

This paper demonstrates a biosensing platform using a silicon nanopillar metasurface coupled with LSPR mediated by cephalexin antibiotics, achieving a 22 nm wavelength shift for sensitive detection.

This study uses human lung organoid-on-chip models to compare host responses to Streptococcus pneumoniae and SARS-CoV-2 variants, showing strain-specific infection and immune responses.

This study examines gait changes in adolescent pigs after mTBI, finding balance impairments and altered movement patterns similar to humans.

This study develops a pipeline to generate brain connectomes using photoacoustic ultrasound in mice, showing comparable results to fMRI in detecting known connections.

This paper develops an optical method to directly detect factor Xa activity in whole blood, enabling rapid anticoagulant monitoring and personalized treatment.

This paper describes engineering hematopoietic stem cells to produce CCR5 knockout cells and secrete HIV-1 inhibiting antibodies, aiming for a one-time cure for HIV-1.

This paper introduces a compact refractive AOSLO system for wide-field retinal imaging in mice, revealing microglial interactions with transplanted neurons and immune responses.

This study examines how adding P2O5 affects the structure, crystallization, and bioactivity of silicate-based bioactive glasses and glass-ceramics, finding it enhances bioactivity but delays ion release in glass-ceramics.

This paper introduces MIDAS, a method to rapidly optimize protein function in mammalian cells, demonstrating its effectiveness in improving a neurotransmitter indicator.

This paper develops ApoFilter, an aptamer-based method to remove lipoproteins from blood, enabling ultra-pure extracellular vesicle isolation with high efficiency and minimal EV loss.

This paper introduces a method to rapidly fabricate PDMS-based organ-on-a-chip devices using 3D printing and epoxy coatings, enabling accessible and scalable microfluidic systems for biological applications.

This paper develops scalable platinum-silicon microneedles for EEG biosensing, showing they match traditional electrodes in signal quality while improving comfort and ease of use.

This paper describes a method to create bioengineered mouse lungs using decellularized scaffolds and human endothelial cells, followed by orthotopic transplantation.

The paper introduces MFAST, a diagnostic chip for rapid, sensitive, and specific detection of Leishmania species, enabling duplex detection and stable performance in low-resource settings.

This study shows elevated hydrostatic pressure affects VE-cadherin junctions via piezo-1, with effects dependent on shear stress duration and intensity.