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The paper uses SMART-epi to study how m6A modification affects RNP granule assembly and RNA interactions, revealing functional divergence among YTHDF proteins.

DeepDiffusion detects heterogeneous diffusion in single-molecule trajectories using a physics-informed neural network, accurately identifying subtle changes despite large errors.

This paper demonstrates that flavoproteins like cryptochrome and iLOV exhibit optically detected magnetic resonance, enabling magnetic field sensing and photoluminescence modulation via radiofrequency pulses.

This study shows that phosphorylated serine clusters in HP1 can sense metal ions, altering phase separation behavior through metal coordination.

The paper demonstrates that bacterial flagellar torque has two components driving spin and precession, supported by bead assay experiments and a mechanical model.

The paper introduces an efficient method for detecting double helix structures in 3D single-molecule microscopy using steerable filters, achieving state-of-the-art performance with minimal user input.

This study uses MD simulations to show that preorganized thumb-subdomain motions in SARS-CoV-2 polymerase drive functional transitions through structurally coupled regulatory regions.

This paper evaluates cross-talk between fluorescent proteins and NADH FLIM, identifying compatible FPs and providing a pipeline to manage cross-excitation in metabolic imaging.

This study uses optical tweezers and FRET microscopy to measure vinculin dynamics under force, finding that recruitment depends on trap stiffness rather than force magnitude.

This study evaluates RF heating of bipolar epicardial leads during MRI at 0.55 T and 1.5 T, showing field strength and termination conditions affect heating patterns and safety.

This study uses atomistic simulations to show how RNA bacteriophages balance genome confinement and delivery through solvent ordering and RNA-protein interactions.

This paper introduces a fluorescence-based microscale platform to study bacterial translation initiation, revealing the dissociation constant of streptomycin and the effect of antimicrobial peptides.

The paper adapts Micro-PIV to study contractile dynamics of poroelastic gels, revealing common deformation features and enabling stress inference.

This study identifies a bacterial choline transporter with a structure and mechanism similar to the human CHT1 transporter, revealing conserved choline translocation pathways.

This study uses in-cell cryo-electron tomography to compare how type I and type II kinase inhibitors affect LRRK2-I2020T filament formation and microtubule association in cells.

The paper investigates intracellular heat dissipation mechanisms and finds that non-diffusive heat dissipation causes slow temperature relaxation in living cells compared to homogeneous solutions.

This study shows non-equilibrium vibrational dynamics dominate ultrafast electron transfer in ErCry4a, challenging Marcus theory and refining spectroscopic interpretations.

The paper shows that neglecting electrical forces in synaptic cleft models leads to significant errors in ionic concentration predictions, demonstrating the necessity of using the full PNP equations.

The paper uses molecular dynamics simulations and electrophysiology to study conformational changes in TMEM16A upon inhibitor removal, revealing conductive and non-conductive states and mechanisms of Ca2+-dependent gating.

This paper identifies a coral opsin, AtAntho2c, that can autonomously regenerate its inactive state through thermal isomerization of retinal, enabling repeated light responses without exogenous retinal.