W. E. Moerner

Organization of Myosin H in the Apical Complex of Toxoplasma Gondii Revealed by 3D Single-Molecule Super-Resolution Microscopy

This paper uses 3D single-molecule super-resolution microscopy to determine the orientation of Myosin H in the apical complex of Toxoplasma gondii, revealing differences in radial organization between its N- and C-termini.

Super-Resolution Atlas of SARS-CoV-2 Infection Reveals Protease-Dependent Organelle Maturation, dsRNA Landscapes, and Intracellular Structural Proteins

This paper creates a super-resolution atlas of SARS-CoV-2 infection, revealing protease-dependent organelle maturation, dsRNA structures, and structural proteins, with implications for antiviral strategies.

Efficient Double Helix Detection with Steerable Filters

The paper introduces an efficient method for detecting double helix structures in 3D single-molecule microscopy using steerable filters, achieving state-of-the-art performance with minimal user input.

Interferometric Image Scanning Microscopy for label-free imaging at 120 nm resolution inside live cells

This paper introduces iISM, a label-free imaging technique with 120 nm resolution for live cell imaging, reducing photodamage and enabling long-term observation of subcellular structures.

Exploring transient states of PAmKate to enable improved cryogenic single-molecule imaging

This study investigates the photophysical properties of PAmKate to enhance cryogenic single-molecule imaging by improving emitter localization rates through a 2-color bleaching process.

Activated interstitial macrophages are a predominant target of viral takeover and focus of inflammation in COVID-19 initiation in human lung

This paper identifies activated interstitial macrophages as a key target of SARS-CoV-2 infection in human lung tissue, showing their role in viral takeover, inflammation, and fibrosis.

Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation

This paper introduces GalNAzMe, a monosaccharide probe that selectively labels O-GalNAc glycosylation in living cells, enabling detailed study of this cancer-relevant modification.