David Rueda

The paper shows that negative supercoiling enables TOP3α to resolve DNA braids by melting crossings into single-stranded DNA, facilitated by TRR and RPA.

This study visualizes human INO80's activity on DNA, showing it rapidly moves nucleosomes between chromatin barriers through directional reversal and boundary confinement.

The paper shows that mouse metaphase chromosomes from different cell types have distinct biomechanical properties, with ESC-derived chromosomes showing conserved force-dependent responses but differing from those of NSCs and preB cells.

This study shows ANKLE1 is a tension-stimulated endonuclease that cleaves DNA branchpoints under high tension, aiding in resolving interchromosomal bridges during mitosis.

DeepDiffusion detects heterogeneous diffusion in single-molecule trajectories using a physics-informed neural network, accurately identifying subtle changes despite large errors.

This study investigates the role of HSV-1 UL9 in DNA looping and finds it does not efficiently loop oriS but can form large loops at non-origin sequences and tether intermolecular oriS DNA.

This study identifies conserved helical motifs in Ikaros that mediate NuRD interaction and transcriptional repression in pre-B cells and B-ALL.

The paper investigates how promoter activation states influence the 3D folding of the HoxB locus in mouse ES cells using simulations and single-cell imaging.