Discover, rate, and discuss biology preprints.

SINGER improves ARG reconstruction accuracy and uncertainty quantification for large genomic samples by enabling efficient posterior sampling.

The paper develops a method to infer dispersal parameters and effective population density in spatially heterogeneous populations using shared haplotype segments.

The paper reports suspected H5N1 avian influenza cases in penguins and shags in Antarctica using PCR, indicating the virus's spread to the region.

This study shows that dietary restriction does not extend the lifespan of Drosophila WS model flies and may even be detrimental, suggesting a role for the WRN exonuclease domain in metabolism.

The paper investigates the mechanisms behind the high incidence of 22q11.2 deletion syndrome by analyzing recombination events and paralogous structures in LCR22 regions.

This paper investigates the role of H3K4 methylation in Mucorales fungi, showing it regulates development, DNA repair, and virulence through genetic and phenotypic analyses of set1 knockout strains.

This study identifies CNTNAP5 as a candidate gene for glaucomatous neurodegeneration through zebrafish knockdown experiments showing retinal degeneration and behavioral changes.

This study analyzes mitochondrial and Y-chromosome haplogroups in the Iranian population using whole-exome sequencing and SNP microarray data from 18,184 individuals, revealing patterns of genetic diversity and haplogroup distribution.

This paper uses ancient genomes to trace the spread of Germanic languages in Europe, identifying a Baltic origin and migration patterns that challenge traditional timelines.

Admix-kit provides tools for genetic analysis of admixed populations, enabling simulation, association testing, and polygenic scoring.

This study identifies a CLASP1 variant in a consanguineous family linked to lissencephaly, showing it disrupts microtubule interactions and contributes to brain development defects.

The paper uses scRNA-seq to study NR2E3 mutations in mouse retinas, identifying hybrid photoreceptors and their role in disease.

The paper introduces GIS-FA, a method integrating GIS, factor-analytic models, and envirotyping to predict cultivar performance in untested environments and support decision-making.

The paper shows that within-group heritability cannot determine the genetic vs. environmental basis of between-group phenotypic differences, using mathematical analysis and simulations.

This study evaluates the functional impact of genetic variants using a high-throughput prime editing sensor strategy, identifying both known and novel TP53 variants with diverse effects on p53 function.

The paper improves genomic prediction of agronomic traits in maize by integrating spatio-temporal modeling of multi-spectral aerial images with genetic data.

The paper shows that TE sequence and conservation features predict their phenotypic relevance, with ERV1 TEs being an exception due to their unique role in environmental interactions.

The paper validates a pharmacogenomics reporting workflow using the Illumina Global Screening Array for 25 genes, showing high accuracy and reproducibility across multiple reference datasets.

This study investigates the molecular and metabolic effects of PKP2 knockdown in a guinea pig ARVC model, revealing ECM remodeling and metabolic changes associated with the disease.

The paper identifies ASAR lncRNAs as regulators of DNA replication timing through interactions with hnRNP proteins, showing their role in chromosome stability and replication synchronization.