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This study shows that bradykinin contributes to vasogenic edema in murine cerebral malaria, and its inhibition improves outcomes when combined with artesunate.

This study examines sex-dependent effects of glutamine supplementation on metabolic disorders, intestinal barrier function, and gut microbiota in diet-induced obese mice, finding protective effects in males and harmful effects in females.

This study introduces spatial-GPT, a platform for spatial glycan, protein, and transcriptome profiling in human liver tissues, revealing glyco-codes that define disease states and progression.

This study shows that ERK overactivation contributes to endothelial cell hyperproliferation in HHT, suggesting ERK inhibition as a potential therapy.

SCALE3D improves prostate cancer risk prediction by analyzing 3D cell interactions through supercell graphs, outperforming traditional features and reducing computational demands.

This study identifies Menacanthus stamineus as the causative louse species in Bangladesh's battery-caged layer farms and documents its negative impacts on bird health and productivity.

This study uses human liver organoids to model Wolman disease, showing multicellular interactions drive disease features and therapeutic responses.

This study identifies CD8+TOX+ T-cells as a specific marker for autoimmune hepatitis using single-nucleus RNA sequencing.

This study uses correlative light and electron microscopy to analyze Lewy body pathology in Parkinson's and dementia with Lewy bodies, revealing regional differences in ultrastructure and mitochondrial changes.

This study shows PFOS worsens atherosclerosis by expanding Bacteroides caecimuris, altering bile acids, and activating FXR-TLR3 signaling in the gut.

This study compares histopathological features of three diabetic kidney disease models, finding that Akita and STZ models show clear structural changes while db/db models require electron microscopy for accurate assessment.

The paper uses NanoString nCounter analysis to compare gene expression in colorectal carcinomas with invasive margins of expansive and infiltrative types, finding distinct signaling pathway and immune process patterns.

This study shows that platelet GARP activates TGF-β1 to limit inflammation and promote cardiac repair after myocardial infarction.

This paper introduces HiViTAlign, a computational pipeline that reassembles fragmented histopathological tissue sections using a vision transformer model, enabling spatial reconstruction of tissue fragments without ground truth.

This study shows that loss of HIF1α in smooth muscle cells in atherosclerosis leads to oxidative stress, increased SMC proliferation, and plaque expansion.

This study identifies hypusine signaling as a driver of vascular smooth muscle cell proliferation in restenosis and shows that inhibiting DHPS reduces neointimal hyperplasia in preclinical models and human tissue.

This study shows that Eed deficiency in hepatocytes causes liver injury, fibrosis, and altered regeneration by disrupting H3K27me3 regulation of pro-regenerative genes.

This study investigates TWEAK and Fn14 expression in human osteoarthritis cartilage and finds TWEAK induces RANKL release from chondrocytes.

The paper introduces a modular AI framework for ROI selection in spatial profiling, showing hybrid generalist-specialist strategies balance signal preservation, concordance, consistency, and efficiency.

This study uses transcriptomic profiling to identify metabolic, inflammatory, and oxidative stress pathways in diabetic porcine wound healing, supporting the model for therapeutic testing.