Author

Zhen Xu

Shanghai Jiao Tong University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Cancer Biology· 2 Bioinformatics· 1 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Amy Grayson· 1 shared B Liu· 1 shared Bingqiu XiuiD· 1 shared Chao Yuan· 1 shared Chenyu LiiD· 1 shared Chuqian LiangiD· 1 shared Elio AdibiD· 1 shared Fan YangiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperCancer Biology

Amy Grayson

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

PFOS aggravates atherosclerosis via Bacteroides caecimuris expansion-driven bile acid remodeling and subsequent intestinal FXR-TLR3 signaling cascade

Lu Jiang, S W Huang, Zhen Xu, Rongxin Guo, Jiahui Zhu, Haowei Liang, Chao Yuan, Zhenghao Zhao, Fengyuan Lv, Yutong Ai, Ke Xu, Yutong Wu, Xin Li, Guoqiang Qin, Chenyu Li, , Z. Y. Fang

This study shows PFOS worsens atherosclerosis by expanding Bacteroides caecimuris, altering bile acids, and activating FXR-TLR3 signaling in the gut.

bioRxiv · Jul 8, 2026 · PreprintPathology

Circadian misalignment underlies immune escape in breast cancer

Chuqian Liang, Zunpeng Liu, Xiaoke Xu, Zhen Xu, Qi Zhang, Tao Zhang, Riley J. Mangan, Bingqiu Xiu, Gongwei Wu, Tara K. Akhshi, Zachary M. Sandusky, G. Kenneth Gray, Na Zhang, Genevra M. Kuziel, Nicole A. Traphagen, , Myles Brown

The paper identifies circadian misalignment between cancer and immune cells in breast tumors as a mechanism of immune evasion and therapeutic resistance.

bioRxiv · May 29, 2026 · PreprintCancer Biology

Genomic Surveillance Reveals Global Spread of Macrolide-Resistant Bordetella pertussis Linked to Vaccine Changes

Zhen Xu, Zhuoying Huang, Lingyue Yuan, Huanyu Wu, Xin Chen, Min Chen, Yuan Zhuang, Jun Feng

The paper analyzes genomic data from Bordetella pertussis isolates to show increased macrolide resistance and spread of a specific lineage linked to vaccine changes.

Journal of Clinical Microbiology · Nov 14, 2025Peer-reviewedMicrobiology

Downregulation of acetyl-CoA carboxylase suppresses the malignant progression of oral cancer

Zhen Xu, Guodong Jia

This study shows that reducing ACACA expression suppresses oral cancer growth and enhances cisplatin's effect on ferroptosis.

Biotechnic & Histochemistry · Sep 12, 2025Peer-reviewedCancer Biology

BioinAI: a general bioinformatic framework for multi-level transcriptomic data analysis using multiple semi-agents

Mintian Cui, Shixi Wang, Fan Yang, Yifei Wang, Fanyu Kong, Ni Kong, Mengying Li, Xiaoyue Qiao, Zhen Xu, Ziyu Yan, Yu Yan, Jiamo Zhang, Kun Chen

BioinAI introduces a framework with algorithms DeepAdvancer and stNiche to analyze transcriptomic data, revealing inflammatory axes and cellular niches across skin conditions.

bioRxiv · Jul 21, 2025 · PreprintBioinformatics