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This study shows that e-cig vapor exposure damages vocal fold mucosa by causing lipid-mediated epithelial injury and disrupting immune responses.

This study evaluates phospho-β-catenin expression in primary and metastatic melanomas and finds no significant differences in staining location or intensity between the two, but notes high expression in dividing cells.

This study shows that FLCN gene ablation reduces fibrosis and inflammation in a diet-induced NASH model by enhancing autophagy and lysosomal biogenesis.

This study shows that Pseudomonas aeruginosa secretion causes acute emphysema in mice, which requires immune suppression and recapitulates human COPD features.

This study shows that in vitro cellular aging models can reflect multi-tissue epigenetic aging in vivo, using DNAmCULTURE as a measure that tracks aging across tissues and responds to interventions.

This paper evaluates an ensemble learning approach for automated knee cartilage segmentation using MR images from the Osteoarthritis Initiative, achieving high Dice coefficients and improved anatomical validity.

This study examines ACE2 and SARS-CoV-2 expression in normal and COVID-19 pancreas tissues, finding prominent ACE2 expression in ductal epithelium and microvasculature, with limited endocrine cell expression and no strong evidence of SARS-CoV-2 infection of endocrine cells.

This study shows that flagellin from Pseudomonas aeruginosa increases TMPRSS2 expression in airway epithelial cells, enhancing SARS-CoV-2 infectivity, particularly in CFTR-deficient cells.

This study shows that Stx2 induces cognitive deficits and inflammation in the hippocampus independently of ERK 1/2 signaling, while LPS requires ERK 1/2 for NF-kB activation.

This paper investigates how Esteya vermicola colonizes pine trees and interacts with Bursaphelenchus xylophilus, revealing specific infection mechanisms and colonization patterns in healthy and infected trees.

This study identifies CSTB as a regulator of histone H3 tail clipping in NPCs and links its deficiency to epigenetic dysregulation and impaired mitochondrial function in a mouse model of progressive myoclonus epilepsy.

This study shows that Wt1-expressing peritoneal mesothelial cells in postnatal and adult mice have limited differentiative capacity, only maintaining themselves and not contributing to other visceral tissues or blood vessels.

The paper analyzes SARS-CoV-2 quasispecies structure using SMRT sequencing, revealing a One-King model with dominant and minor haplotypes and their evolutionary dynamics.

The paper characterizes SARS-CoV-2 susceptible cells and develops a focus forming assay to detect and quantify neutralizing antibodies in sera samples.

This paper develops a deep learning model to detect BRAF mutations in melanoma histopathology images using whole slide images from 256 patients, achieving AUC scores of 0.96 and 0.72.

The paper analyzes genetic variability in wheat curl mites and mite-transmissible viruses in Colorado, identifies resistance sources in wheat germplasm, and finds variation in virus resistance among wheat varieties.

This study examines the expression of ACE2, TMPRSS2, and CTSL in human airway epithelial cells under various physiological and pathological conditions and finds associations with SARS-CoV-2 infection risk.

The paper introduces a framework combining graph neural networks and topological data analysis to extract and visualize features from whole-slide images, demonstrating its application in colon cancer staging.

This study investigates how vascular calcification affects phosphate handling in rats, finding that calcified arteries preferentially take up phosphate during acute challenges.

The paper compares lipidome profiles of plasma microvesicles in experimental cerebral malaria and non-CM malaria, finding distinct lipid changes associated with CM.