Author

M. Paquette

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 4 Biophysics· 1 Cancer Biology· 1 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 2 Organism:mouse· 2

Frequent Co-Authors

O. Le Blanc· 4 shared P. Brassard· 4 shared S. Imhoff· 4 shared A. Drapeau· 3 shared A. Pause· 3 shared L. El-Houjeiri· 3 shared L. Labrecque· 3 shared S. Malenfant· 3 shared

Activity by Year

2017-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersPhysiology

O. Le Blanc

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

AMPK-dependent phosphorylation is required for transcriptional activation of TFEB/TFE3

M. Paquette, L. El-Houjeiri, L. C. Zirden, P. Puustinen, P. Blanchette, H. Jeong, K. Dejgaard, P. M. Siegel, A. Pause

This study shows that AMPK-dependent phosphorylation of TFEB/TFE3 enhances their transcriptional activity under nutrient starvation and promotes chemoresistance in cancer.

bioRxiv · Jan 27, 2021Cancer Biology

Axon Diameter Measurements using Diffusion MRI are Infeasible

M. Paquette, C. Eichner, T. R. Knösche, A. Anwander

This paper demonstrates that quantifying axon diameters using diffusion MRI is infeasible due to limitations in detecting small axons and the bias of effective diameter metrics.

bioRxiv · Oct 1, 2020 · PreprintBiophysics

FLCN Gene Ablation Reduces Fibrosis and Inflammation in a Diet-Induced NASH Model

M. Paquette, M. Yan, L. El-Houjeiri, M. Biondini, J. M. J. Ramirez-Reyes, A. Pacis, H. Jeong, J. L. Estall, P. M. Siegel, A. Pause

This study shows that FLCN gene ablation reduces fibrosis and inflammation in a diet-induced NASH model by enhancing autophagy and lysosomal biogenesis.

bioRxiv · Sep 10, 2020 · PreprintPathology

Dynamic cerebral autoregulation of endurance-trained men following 6 weeks of high-intensity interval training to exhaustion

A. Drapeau, L. Labrecque, S. Imhoff, M. Paquette, O. Le Blanc, S. Malenfant, P. Brassard

This study shows that 6 weeks of high-intensity interval training to exhaustion reduces dynamic cerebral autoregulation in endurance-trained men, without affecting resting cerebral blood flow.

bioRxiv · Apr 11, 2019Physiology

Cardiac remodeling after six weeks of high-intensity interval training to exhaustion in endurance-trained males

H. Mahjoub, O. Le Blanc, M. Paquette, S. Imhoff, L. Labrecque, A. Drapeau, P. Poirier, E. Bedard, P. Pibarot, P. Brassard

This study examines the cardiovascular effects of high-intensity interval training (HIIT) in endurance-trained males, finding reduced blood pressure and increased left atrial volumes, with submaximal HIIT negatively affecting right ventricular function.

bioRxiv · Mar 20, 2019Physiology

The transcription factors TFEB and TFE3 link the FLCN-AMPK signaling axis to innate immune response and pathogen resistance

L. El-Houjeiri, E. Possik, T. Tarika Vijayaraghavan, M. Paquette, J. A. Martina, J. M. Kazan, E. H. Ma, R. Jones, P. Blanchette, R. Puertollano, A. Pause

This study identifies a conserved mechanism linking FLCN-AMPK signaling to TFEB/TFE3 activation, enhancing innate immunity and pathogen resistance across species.

bioRxiv · Nov 6, 2018Immunology

Functional implications of impaired dynamic cerebral autoregulation in young healthy women; a comparative investigation

L. Labreque, K. Rahimaly, S. Imhoff, M. Paquette, O. Le Blanc, S. Malenfant, A. Drapeau, J. D. Smirl, D. M. Bailey, P. Brassard

This study compares dynamic cerebral autoregulation (dCA) between young healthy women and men, finding impaired dCA in women despite similar prevalence of orthostatic hypotension.

bioRxiv · Sep 3, 2018Physiology

Diminished dynamic cerebral autoregulatory capacity with forced oscillations in mean arterial pressure with elevated cardiorespiratory fitness

L. Labrecque, K. Rahimaly, S. Imhoff, M. Paquette, O. Le Blanc, S. Malenfant, S. J. Lucas, D. M. Bailey, J. D. Smirl, P. Brassard

This study examines how cardiorespiratory fitness affects dynamic cerebral autoregulatory capacity during changes in mean arterial pressure, finding delayed regulation onset in athletes but comparable TFA metrics during spontaneous oscillations.

bioRxiv · Sep 28, 2017Physiology