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This study examines spatial lipid changes in SIV-infected macaques on ART, finding region-specific lipid alterations that suggest ongoing bioenergetic disruptions in the brain.

This study uses spatial transcriptomics to analyze SARS-CoV-2 infection in coronary endothelial and myocardial tissues from COVID-19 patients, finding unique pro-inflammatory profiles in capillaries but not larger vessels.

This paper develops a multi-model platform to study atrial fibrillation-associated genes, identifying phospholamban as a key regulator of cardiac rhythm through interactions with calcium handling proteins.

This study uses interpretable deep learning to identify myelin pallor in brain tissue associated with cognitive impairment from postmortem human samples.

The paper analyzes HER2-positive breast cancer tumors at the single-cell level to identify phenotypic heterogeneity and its implications for response to HER2-targeted therapies.

The paper develops a single-cell MRD assay that detects residual leukemic clones with high sensitivity and reveals clonal architecture in AML.

This study shows that FGF21 overexpression in the liver reduces lipotoxicity, inflammation, and fibrosis in NASH by blocking lipid influx and macrophage activation.

This study compares dimethyl fumarate (DMF) and prednisone (PRED) in mdx mice, finding DMF improves muscle function and mitochondrial health while PRED causes side effects.

This study identifies VCAM-1 upregulation as a key marker of AKI-to-CKD transition, distinct from KIM-1, through mouse models and human single-cell transcriptomics.

This study shows that continuous hypoxia rescues retinal ganglion cell degeneration in a mouse model of mitochondrial optic neuropathy, though the effect is not sustained at later time points.

This study investigates pulmonary lesions in rats exposed to titanium dioxide nanoparticles, identifying a new lesion type called pulmonary dust foci associated with pneumoconiosis-like effects.

The paper investigates the pathology of African swine fever in naturally infected wild boar, finding that variant IV causes a protracted disease course with lower viral load but more chronic lesions.

This study identifies an IgE/mast cell/B cell amplification loop that drives abdominal aortic aneurysm progression by promoting IL-4 production and subclinical fissure healing impairment.

This study shows that PRR antagonism reduces hepatic steatosis and fibrosis in NAFLD models without affecting body weight or glucose levels.

This study examines how serum from chronic heat-not-burn cigarette smokers affects cardiac stromal cells, showing increased fibrosis and reduced paracrine support.

This study shows that blocking GDF15 reduces severe heart failure and cardiac cachexia in mice by preventing weight loss and slowing disease progression.

The paper uses spatial proteomics to compare fibrotic and non-fibrotic airway cells in UIP, finding deregulated pathways and identifying key proteins associated with mucin biogenesis and ciliogenesis.

This study investigates the effect of titanium dioxide application on Fusarium wilt incidence, severity, and tomato yield in three tomato accessions, finding that 1.3 ml/l TiO2 significantly reduces disease and improves yield.

This study compares immune landscapes of non-progressing and progressing cutaneous squamous cell carcinomas to identify immune features associated with metastasis.

This study shows that LOX-dependent matrix stiffening, regulated by RAGE, promotes retinal endothelial activation in diabetes, suggesting new therapeutic targets for diabetic retinopathy.